Li Y - Search Results

1

Expanded GAA repeats impede transcription elongation through the FXN gene and induce transcriptional silencing that is restricted to the FXN locus.

Li Y, Lu Y, Polak U, Lin K, Shen J, Farmer J, Seyer L, Bhalla AD, Rozwadowska N, Lynch DR, Butler JS, Napierala M. Li Y, et al. Hum Mol Genet. 2015 Dec 15;24(24):6932-43. doi: 10.1093/hmg/ddv397. Epub 2015 Sep 23. Hum Mol Genet. 2015. PMID: 26401053 Free PMC article.

2

Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.

Li Y, Polak U, Bhalla AD, Rozwadowska N, Butler JS, Lynch DR, Dent SYR, Napierala M. Li Y, et al. Mol Ther. 2015 Jun;23(6):1055-1065. doi: 10.1038/mt.2015.41. Epub 2015 Mar 11. Mol Ther. 2015. PMID: 25758173 Free PMC article.

3

Establishment and Maintenance of Primary Fibroblast Repositories for Rare Diseases-Friedreich's Ataxia Example.

Li Y, Polak U, Clark AD, Bhalla AD, Chen YY, Li J, Farmer J, Seyer L, Lynch D, Butler JS, Napierala M. Li Y, et al. Among authors: li j. Biopreserv Biobank. 2016 Aug;14(4):324-9. doi: 10.1089/bio.2015.0117. Epub 2016 Mar 22. Biopreserv Biobank. 2016. PMID: 27002638 Free PMC article.

4

Alleviating GAA Repeat Induced Transcriptional Silencing of the Friedreich's Ataxia Gene During Somatic Cell Reprogramming.

Polak U, Li Y, Butler JS, Napierala M. Polak U, et al. Among authors: li y. Stem Cells Dev. 2016 Dec 1;25(23):1788-1800. doi: 10.1089/scd.2016.0147. Epub 2016 Oct 17. Stem Cells Dev. 2016. PMID: 27615158 Free PMC article.

5

Comprehensive analysis of gene expression patterns in Friedreich's ataxia fibroblasts by RNA sequencing reveals altered levels of protein synthesis factors and solute carriers.

Napierala JS, Li Y, Lu Y, Lin K, Hauser LA, Lynch DR, Napierala M. Napierala JS, et al. Among authors: li y. Dis Model Mech. 2017 Nov 1;10(11):1353-1369. doi: 10.1242/dmm.030536. Dis Model Mech. 2017. PMID: 29125828 Free PMC article.

6

Premature transcription termination at the expanded GAA repeats and aberrant alternative polyadenylation contributes to the Frataxin transcriptional deficit in Friedreich's ataxia.

Li Y, Li J, Wang J, Zhang S, Giles K, Prakash TP, Rigo F, Napierala JS, Napierala M. Li Y, et al. Among authors: li j. Hum Mol Genet. 2022 Oct 10;31(20):3539-3557. doi: 10.1093/hmg/ddac134. Hum Mol Genet. 2022. PMID: 35708503 Free PMC article.

7

Deep sequencing of mitochondrial genomes reveals increased mutation load in Friedreich's ataxia.

Bhalla AD, Khodadadi-Jamayran A, Li Y, Lynch DR, Napierala M. Bhalla AD, et al. Among authors: li y. Ann Clin Transl Neurol. 2016 Jun 14;3(7):523-36. doi: 10.1002/acn3.322. eCollection 2016 Jul. Ann Clin Transl Neurol. 2016. PMID: 27386501 Free PMC article.

8

Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy.

Li J, Li Y, Wang J, Gonzalez TJ, Asokan A, Napierala JS, Napierala M. Li J, et al. Among authors: li y. Hum Gene Ther. 2020 Aug;31(15-16):839-851. doi: 10.1089/hum.2020.053. Epub 2020 Jul 13. Hum Gene Ther. 2020. PMID: 32527155 Free PMC article.

9

Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.

Li Y, Li J, Wang J, Lynch DR, Shen X, Corey DR, Parekh D, Bhat B, Woo C, Cherry JJ, Napierala JS, Napierala M. Li Y, et al. Among authors: li j. Nucleic Acids Res. 2021 Nov 18;49(20):11560-11574. doi: 10.1093/nar/gkab954. Nucleic Acids Res. 2021. PMID: 34718736 Free PMC article.

10

Efficient electroporation of neuronal cells using synthetic oligonucleotides: identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression.

Shen X, Beasley S, Putman JN, Li Y, Prakash TP, Rigo F, Napierala M, Corey DR. Shen X, et al. Among authors: li y. RNA. 2019 Sep;25(9):1118-1129. doi: 10.1261/rna.071290.119. Epub 2019 May 31. RNA. 2019. PMID: 31151992 Free PMC article.

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