Carr D - Search Results

1

Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T. Howe JA, et al. Among authors: carr d. Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30. Nature. 2015. PMID: 26416753

2

Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor.

Walker SS, Degen D, Nickbarg E, Carr D, Soriano A, Mandal M, Painter RE, Sheth P, Xiao L, Sher X, Murgolo N, Su J, Olsen DB, Ebright RH, Young K. Walker SS, et al. Among authors: carr d. ACS Chem Biol. 2017 May 19;12(5):1346-1352. doi: 10.1021/acschembio.6b01133. Epub 2017 Mar 31. ACS Chem Biol. 2017. PMID: 28323406 Free PMC article.

3

Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.

Fischmann TO, Smith CK, Mayhood TW, Myers JE, Reichert P, Mannarino A, Carr D, Zhu H, Wong J, Yang RS, Le HV, Madison VS. Fischmann TO, et al. Among authors: carr d. Biochemistry. 2009 Mar 31;48(12):2661-74. doi: 10.1021/bi801898e. Biochemistry. 2009. PMID: 19161339

4

Expression and purification of phosphorylated and non-phosphorylated human MEK1.

Smith CK, Carr D, Mayhood TW, Jin W, Gray K, Windsor WT. Smith CK, et al. Among authors: carr d. Protein Expr Purif. 2007 Apr;52(2):446-56. doi: 10.1016/j.pep.2006.11.002. Epub 2006 Nov 9. Protein Expr Purif. 2007. PMID: 17175166

5

Development of a fully automated platform for agar-based measurement of viable bacterial growth.

Squadroni B, Newhard W, Carr D, Trinh H, Racine F, Zuck P, Howell B, Hazuda DJ, Cassaday J. Squadroni B, et al. Among authors: carr d. SLAS Technol. 2022 Aug;27(4):247-252. doi: 10.1016/j.slast.2022.03.003. Epub 2022 Mar 30. SLAS Technol. 2022. PMID: 35367399 Free article.

6

A translational pharmacokinetic/pharmacodynamic model to characterize bacterial kill in the presence of imipenem-relebactam.

Bhagunde P, Zhang Z, Racine F, Carr D, Wu J, Young K, Rizk ML. Bhagunde P, et al. Among authors: carr d. Int J Infect Dis. 2019 Dec;89:55-61. doi: 10.1016/j.ijid.2019.08.026. Epub 2019 Aug 31. Int J Infect Dis. 2019. PMID: 31479762 Free article.

7

Exploring the Pharmacokinetic/Pharmacodynamic Relationship of Relebactam (MK-7655) in Combination with Imipenem in a Hollow-Fiber Infection Model.

Wu J, Racine F, Wismer MK, Young K, Carr DM, Xiao JC, Katwaru R, Si Q, Harradine P, Motyl M, Bhagunde PR, Rizk ML. Wu J, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02323-17. doi: 10.1128/AAC.02323-17. Print 2018 May. Antimicrob Agents Chemother. 2018. PMID: 29507068 Free PMC article.

8

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors.

Morris EJ, Jha S, Restaino CR, Dayananth P, Zhu H, Cooper A, Carr D, Deng Y, Jin W, Black S, Long B, Liu J, Dinunzio E, Windsor W, Zhang R, Zhao S, Angagaw MH, Pinheiro EM, Desai J, Xiao L, Shipps G, Hruza A, Wang J, Kelly J, Paliwal S, Gao X, Babu BS, Zhu L, Daublain P, Zhang L, Lutterbach BA, Pelletier MR, Philippar U, Siliphaivanh P, Witter D, Kirschmeier P, Bishop WR, Hicklin D, Gilliland DG, Jayaraman L, Zawel L, Fawell S, Samatar AA. Morris EJ, et al. Among authors: carr d. Cancer Discov. 2013 Jul;3(7):742-50. doi: 10.1158/2159-8290.CD-13-0070. Epub 2013 Apr 24. Cancer Discov. 2013. PMID: 23614898

9

Discovery of novel, dual mechanism ERK inhibitors by affinity selection screening of an inactive kinase.

Deng Y, Shipps GW Jr, Cooper A, English JM, Annis DA, Carr D, Nan Y, Wang T, Zhu HY, Chuang CC, Dayananth P, Hruza AW, Xiao L, Jin W, Kirschmeier P, Windsor WT, Samatar AA. Deng Y, et al. Among authors: carr d. J Med Chem. 2014 Nov 13;57(21):8817-26. doi: 10.1021/jm500847m. Epub 2014 Oct 22. J Med Chem. 2014. PMID: 25313996

10

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I.

Zhang FL, Kirschmeier P, Carr D, James L, Bond RW, Wang L, Patton R, Windsor WT, Syto R, Zhang R, Bishop WR. Zhang FL, et al. Among authors: carr d. J Biol Chem. 1997 Apr 11;272(15):10232-9. doi: 10.1074/jbc.272.15.10232. J Biol Chem. 1997. PMID: 9092572 Free article.

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