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Sensitivity of plasma BRAFmutant and NRASmutant cell-free DNA assays to detect metastatic melanoma in patients with low RECIST scores and non-RECIST disease progression.
Chang GA, Tadepalli JS, Shao Y, Zhang Y, Weiss S, Robinson E, Spittle C, Furtado M, Shelton DN, Karlin-Neumann G, Pavlick A, Osman I, Polsky D. Chang GA, et al. Among authors: spittle c. Mol Oncol. 2016 Jan;10(1):157-65. doi: 10.1016/j.molonc.2015.09.005. Epub 2015 Sep 25. Mol Oncol. 2016. PMID: 26440707 Free PMC article.
TERT, BRAF, and NRAS Mutational Heterogeneity between Paired Primary and Metastatic Melanoma Tumors.
Chang GA, Wiggins JM, Corless BC, Syeda MM, Tadepalli JS, Blake S, Fleming N, Darvishian F, Pavlick A, Berman R, Shapiro R, Shao Y, Karlin-Neumann G, Spittle C, Osman I, Polsky D. Chang GA, et al. Among authors: spittle c. J Invest Dermatol. 2020 Aug;140(8):1609-1618.e7. doi: 10.1016/j.jid.2020.01.027. Epub 2020 Feb 20. J Invest Dermatol. 2020. PMID: 32087194 Free PMC article.
mTOR is activated in the majority of malignant melanomas.
Karbowniczek M, Spittle CS, Morrison T, Wu H, Henske EP. Karbowniczek M, et al. J Invest Dermatol. 2008 Apr;128(4):980-7. doi: 10.1038/sj.jid.5701074. Epub 2007 Oct 4. J Invest Dermatol. 2008. PMID: 17914450 Free article.
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