Baguley TD - Search Results

1

Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.

Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ. Xu J, et al. Among authors: baguley td. Cell Mol Life Sci. 2016 Apr;73(7):1503-14. doi: 10.1007/s00018-015-2057-1. Epub 2015 Oct 8. Cell Mol Life Sci. 2016. PMID: 26450419 Free PMC article.

2

Inhibition of STEP₆₁ ameliorates deficits in mouse and hiPSC-based schizophrenia models.

Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Xu J, et al. Among authors: baguley td. Mol Psychiatry. 2018 Feb;23(2):271-281. doi: 10.1038/mp.2016.163. Epub 2016 Oct 18. Mol Psychiatry. 2018. PMID: 27752082 Free PMC article.

3

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.

Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E. Azkona G, et al. Pain. 2016 Feb;157(2):377-386. doi: 10.1097/j.pain.0000000000000329. Pain. 2016. PMID: 26270590 Free PMC article.

4

Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.

Baguley TD, Xu HC, Chatterjee M, Nairn AC, Lombroso PJ, Ellman JA. Baguley TD, et al. J Med Chem. 2013 Oct 10;56(19):7636-50. doi: 10.1021/jm401037h. Epub 2013 Oct 1. J Med Chem. 2013. PMID: 24083656 Free PMC article.

5

Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.

Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. Xu J, et al. Among authors: baguley td. PLoS Biol. 2014 Aug 5;12(8):e1001923. doi: 10.1371/journal.pbio.1001923. eCollection 2014 Aug. PLoS Biol. 2014. PMID: 25093460 Free PMC article.

6

Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.

Baguley TD, Nairn AC, Lombroso PJ, Ellman JA. Baguley TD, et al. Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6. doi: 10.1016/j.bmcl.2015.01.020. Epub 2015 Jan 20. Bioorg Med Chem Lett. 2015. PMID: 25666825 Free PMC article.

7

Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.

Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ. Xu J, et al. Among authors: baguley td. J Neurochem. 2016 Jan;136(2):285-94. doi: 10.1111/jnc.13295. Epub 2015 Sep 17. J Neurochem. 2016. PMID: 26316048 Free PMC article.

8

Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases.

Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA. Tjin CC, et al. Among authors: baguley td. ACS Cent Sci. 2017 Dec 27;3(12):1322-1328. doi: 10.1021/acscentsci.7b00486. Epub 2017 Dec 6. ACS Cent Sci. 2017. PMID: 29296673 Free PMC article.

9

Asymmetric synthesis of amines by the Knochel-type MgCl2-enhanced addition of benzyl zinc reagents to N-tert-butanesulfinyl aldimines.

Buesking AW, Baguley TD, Ellman JA. Buesking AW, et al. Among authors: baguley td. Org Lett. 2011 Mar 4;13(5):964-7. doi: 10.1021/ol103002t. Epub 2011 Feb 9. Org Lett. 2011. PMID: 21306151

10

Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.

Rawls KA, Lang PT, Takeuchi J, Imamura S, Baguley TD, Grundner C, Alber T, Ellman JA. Rawls KA, et al. Among authors: baguley td. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6851-4. doi: 10.1016/j.bmcl.2009.10.090. Epub 2009 Oct 25. Bioorg Med Chem Lett. 2009. PMID: 19889539 Free PMC article.

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