Flach J - Search Results

1

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.

Alvarez S, Díaz M, Flach J, Rodriguez-Acebes S, López-Contreras AJ, Martínez D, Cañamero M, Fernández-Capetillo O, Isern J, Passegué E, Méndez J. Alvarez S, et al. Among authors: flach j. Nat Commun. 2015 Oct 12;6:8548. doi: 10.1038/ncomms9548. Nat Commun. 2015. PMID: 26456157 Free PMC article.

2

FOXO3A directs a protective autophagy program in haematopoietic stem cells.

Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. Warr MR, et al. Among authors: flach j. Nature. 2013 Feb 21;494(7437):323-7. doi: 10.1038/nature11895. Epub 2013 Feb 6. Nature. 2013. PMID: 23389440 Free PMC article.

3

Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche.

Schepers K, Pietras EM, Reynaud D, Flach J, Binnewies M, Garg T, Wagers AJ, Hsiao EC, Passegué E. Schepers K, et al. Among authors: flach j. Cell Stem Cell. 2013 Sep 5;13(3):285-99. doi: 10.1016/j.stem.2013.06.009. Epub 2013 Jul 11. Cell Stem Cell. 2013. PMID: 23850243 Free PMC article.

4

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.

Pietras EM, Lakshminarasimhan R, Techner JM, Fong S, Flach J, Binnewies M, Passegué E. Pietras EM, et al. Among authors: flach j. J Exp Med. 2014 Feb 10;211(2):245-62. doi: 10.1084/jem.20131043. Epub 2014 Feb 3. J Exp Med. 2014. PMID: 24493802 Free PMC article.

5

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells.

Flach J, Bakker ST, Mohrin M, Conroy PC, Pietras EM, Reynaud D, Alvarez S, Diolaiti ME, Ugarte F, Forsberg EC, Le Beau MM, Stohr BA, Méndez J, Morrison CG, Passegué E. Flach J, et al. Nature. 2014 Aug 14;512(7513):198-202. doi: 10.1038/nature13619. Epub 2014 Jul 30. Nature. 2014. PMID: 25079315 Free PMC article.

6

Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.

Buchner M, Park E, Geng H, Klemm L, Flach J, Passegué E, Schjerven H, Melnick A, Paietta E, Kopanja D, Raychaudhuri P, Müschen M. Buchner M, et al. Among authors: flach j. Nat Commun. 2015 Mar 10;6:6471. doi: 10.1038/ncomms7471. Nat Commun. 2015. PMID: 25753524 Free PMC article.

7

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis.

Wong JC, Weinfurtner KM, Alzamora Mdel P, Kogan SC, Burgess MR, Zhang Y, Nakitandwe J, Ma J, Cheng J, Chen SC, Ho TT, Flach J, Reynaud D, Passegué E, Downing JR, Shannon K. Wong JC, et al. Among authors: flach j. Elife. 2015 Jul 20;4:e07839. doi: 10.7554/eLife.07839. Elife. 2015. PMID: 26193121 Free PMC article.

8

MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis.

Wang W, Org T, Montel-Hagen A, Pioli PD, Duan D, Israely E, Malkin D, Su T, Flach J, Kurdistani SK, Schiestl RH, Mikkola HK. Wang W, et al. Among authors: flach j. Nat Commun. 2016 Aug 10;7:12376. doi: 10.1038/ncomms12376. Nat Commun. 2016. PMID: 27507714 Free PMC article.

9

Autophagy maintains the metabolism and function of young and old stem cells.

Ho TT, Warr MR, Adelman ER, Lansinger OM, Flach J, Verovskaya EV, Figueroa ME, Passegué E. Ho TT, et al. Among authors: flach j. Nature. 2017 Mar 9;543(7644):205-210. doi: 10.1038/nature21388. Epub 2017 Mar 1. Nature. 2017. PMID: 28241143 Free PMC article.

10

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.

Ho TT, Dellorusso PV, Verovskaya EV, Bakker ST, Flach J, Smith LK, Ventura PB, Lansinger OM, Hérault A, Zhang SY, Kang YA, Mitchell CA, Villeda SA, Passegué E. Ho TT, et al. Among authors: flach j. J Exp Med. 2021 Jul 5;218(7):e20210223. doi: 10.1084/jem.20210223. Epub 2021 May 25. J Exp Med. 2021. PMID: 34032859 Free PMC article.

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