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Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture.
Muir KR, Lima MJ, Docherty HM, McGowan NW, Forbes S, Heremans Y, Forbes SJ, Heimberg H, Casey J, Docherty K. Muir KR, et al. Among authors: heremans y. PLoS One. 2015 Oct 12;10(10):e0140352. doi: 10.1371/journal.pone.0140352. eCollection 2015. PLoS One. 2015. PMID: 26457418 Free PMC article.
Suppression of epithelial-to-mesenchymal transitioning enhances ex vivo reprogramming of human exocrine pancreatic tissue toward functional insulin-producing β-like cells.
Lima MJ, Muir KR, Docherty HM, Drummond R, McGowan NW, Forbes S, Heremans Y, Houbracken I, Ross JA, Forbes SJ, Ravassard P, Heimberg H, Casey J, Docherty K. Lima MJ, et al. Among authors: heremans y. Diabetes. 2013 Aug;62(8):2821-33. doi: 10.2337/db12-1256. Epub 2013 Apr 22. Diabetes. 2013. PMID: 23610058 Free PMC article.
Generation of Functional Beta-Like Cells from Human Exocrine Pancreas.
Lima MJ, Muir KR, Docherty HM, McGowan NW, Forbes S, Heremans Y, Heimberg H, Casey J, Docherty K. Lima MJ, et al. Among authors: heremans y. PLoS One. 2016 May 31;11(5):e0156204. doi: 10.1371/journal.pone.0156204. eCollection 2016. PLoS One. 2016. PMID: 27243814 Free PMC article.
Plasticity of adult human pancreatic duct cells by neurogenin3-mediated reprogramming.
Swales N, Martens GA, Bonné S, Heremans Y, Borup R, Van de Casteele M, Ling Z, Pipeleers D, Ravassard P, Nielsen F, Ferrer J, Heimberg H. Swales N, et al. Among authors: heremans y. PLoS One. 2012;7(5):e37055. doi: 10.1371/journal.pone.0037055. Epub 2012 May 14. PLoS One. 2012. PMID: 22606327 Free PMC article.
Reprogramming of human exocrine pancreas cells to beta cells.
Staels W, Heremans Y, Heimberg H. Staels W, et al. Among authors: heremans y. Best Pract Res Clin Endocrinol Metab. 2015 Dec;29(6):849-57. doi: 10.1016/j.beem.2015.10.001. Epub 2015 Oct 9. Best Pract Res Clin Endocrinol Metab. 2015. PMID: 26696514 Review.
Reprogramming of human pancreatic exocrine cells to β-like cells.
Lemper M, Leuckx G, Heremans Y, German MS, Heimberg H, Bouwens L, Baeyens L. Lemper M, et al. Among authors: heremans y. Cell Death Differ. 2015 Jul;22(7):1117-30. doi: 10.1038/cdd.2014.193. Epub 2014 Dec 5. Cell Death Differ. 2015. PMID: 25476775 Free PMC article.
Ectopic expression of E2F1 stimulates beta-cell proliferation and function.
Grouwels G, Cai Y, Hoebeke I, Leuckx G, Heremans Y, Ziebold U, Stangé G, Chintinne M, Ling Z, Pipeleers D, Heimberg H, Van de Casteele M. Grouwels G, et al. Among authors: heremans y. Diabetes. 2010 Jun;59(6):1435-44. doi: 10.2337/db09-1295. Epub 2010 Mar 18. Diabetes. 2010. PMID: 20299467 Free PMC article.
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