Cuppen E - Search Results

1

Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats.

Chen X, Walther FJ, van Boxtel R, Laghmani EH, Sengers RM, Folkerts G, DeRuiter MC, Cuppen E, Wagenaar GT. Chen X, et al. Among authors: cuppen e. Acta Physiol (Oxf). 2016 Mar;216(3):358-75. doi: 10.1111/apha.12622. Epub 2015 Nov 11. Acta Physiol (Oxf). 2016. PMID: 26495902 Free PMC article.

2

Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis.

van Boxtel R, Toonen PW, van Roekel HS, Verheul M, Smits BM, Korving J, de Bruin A, Cuppen E. van Boxtel R, et al. Among authors: cuppen e. Carcinogenesis. 2008 Jun;29(6):1290-7. doi: 10.1093/carcin/bgn094. Epub 2008 Apr 15. Carcinogenesis. 2008. PMID: 18417481

3

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals.

van Boxtel R, Toonen PW, Verheul M, van Roekel HS, Nijman IJ, Guryev V, Cuppen E. van Boxtel R, et al. Among authors: cuppen e. BMC Genomics. 2008 Oct 7;9:460. doi: 10.1186/1471-2164-9-460. BMC Genomics. 2008. PMID: 18840264 Free PMC article.

4

ENU mutagenesis to generate genetically modified rat models.

van Boxtel R, Gould MN, Cuppen E, Smits BM. van Boxtel R, et al. Among authors: cuppen e. Methods Mol Biol. 2010;597:151-67. doi: 10.1007/978-1-60327-389-3_11. Methods Mol Biol. 2010. PMID: 20013232

5

Systematic generation of in vivo G protein-coupled receptor mutants in the rat.

van Boxtel R, Vroling B, Toonen P, Nijman IJ, van Roekel H, Verheul M, Baakman C, Guryev V, Vriend G, Cuppen E. van Boxtel R, et al. Among authors: cuppen e. Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8. Pharmacogenomics J. 2011. PMID: 20531371 Free PMC article.

6

Rat traps: filling the toolbox for manipulating the rat genome.

van Boxtel R, Cuppen E. van Boxtel R, et al. Among authors: cuppen e. Genome Biol. 2010;11(9):217. doi: 10.1186/gb-2010-11-9-217. Epub 2010 Sep 29. Genome Biol. 2010. PMID: 20887642 Free PMC article. Review.

7

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples.

Nijman IJ, Mokry M, van Boxtel R, Toonen P, de Bruijn E, Cuppen E. Nijman IJ, et al. Among authors: cuppen e. Nat Methods. 2010 Nov;7(11):913-5. doi: 10.1038/nmeth.1516. Epub 2010 Oct 17. Nat Methods. 2010. PMID: 20953175

8

Generation of genetically modified rodents using random ENU mutagenesis.

van Boxtel R, Cuppen E. van Boxtel R, et al. Among authors: cuppen e. Methods Mol Biol. 2011;693:295-308. doi: 10.1007/978-1-60761-974-1_18. Methods Mol Biol. 2011. PMID: 21080288

9

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.

Mul JD, van Boxtel R, Bergen DJ, Brans MA, Brakkee JH, Toonen PW, Garner KM, Adan RA, Cuppen E. Mul JD, et al. Among authors: cuppen e. Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28. Obesity (Silver Spring). 2012. PMID: 21527895 Free PMC article.

10

Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.

van Boxtel R, Kuiper RV, Toonen PW, van Heesch S, Hermsen R, de Bruin A, Cuppen E. van Boxtel R, et al. Among authors: cuppen e. Am J Pathol. 2011 Oct;179(4):1616-22. doi: 10.1016/j.ajpath.2011.06.036. Epub 2011 Aug 18. Am J Pathol. 2011. PMID: 21854749 Free PMC article.

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