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Page 1
Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.
Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius HJ, Al-Hashimi HM, Markovitz DM. Swanson MD, et al. Among authors: king s. Cell. 2015 Oct 22;163(3):746-58. doi: 10.1016/j.cell.2015.09.056. Epub 2015 Oct 22. Cell. 2015. PMID: 26496612 Free PMC article.
A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo.
Covés-Datson EM, King SR, Legendre M, Gupta A, Chan SM, Gitlin E, Kulkarni VV, Pantaleón García J, Smee DF, Lipka E, Evans SE, Tarbet EB, Ono A, Markovitz DM. Covés-Datson EM, et al. Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2122-2132. doi: 10.1073/pnas.1915152117. Epub 2020 Jan 13. Proc Natl Acad Sci U S A. 2020. PMID: 31932446 Free PMC article.
Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
Covés-Datson EM, King SR, Legendre M, Swanson MD, Gupta A, Claes S, Meagher JL, Boonen A, Zhang L, Kalveram B, Raglow Z, Freiberg AN, Prichard M, Stuckey JA, Schols D, Markovitz DM. Covés-Datson EM, et al. Among authors: king sr. Sci Rep. 2021 Jan 12;11(1):656. doi: 10.1038/s41598-020-80577-7. Sci Rep. 2021. PMID: 33436903 Free PMC article.
Genomic flexibility of human endogenous retrovirus type K.
Dube D, Contreras-Galindo R, He S, King SR, Gonzalez-Hernandez MJ, Gitlin SD, Kaplan MH, Markovitz DM. Dube D, et al. Among authors: king sr. J Virol. 2014 Sep 1;88(17):9673-82. doi: 10.1128/JVI.01147-14. Epub 2014 Jun 11. J Virol. 2014. PMID: 24920813 Free PMC article.
Why Do Membranes of Some Unhealthy Cells Adopt a Cubic Architecture?
Xiao Q, Wang Z, Williams D, Leowanawat P, Peterca M, Sherman SE, Zhang S, Hammer DA, Heiney PA, King SR, Markovitz DM, André S, Gabius HJ, Klein ML, Percec V. Xiao Q, et al. Among authors: king sr. ACS Cent Sci. 2016 Dec 28;2(12):943-953. doi: 10.1021/acscentsci.6b00284. Epub 2016 Dec 5. ACS Cent Sci. 2016. PMID: 28058284 Free PMC article.
Inhibition of Ebola Virus by a Molecularly Engineered Banana Lectin.
Covés-Datson EM, Dyall J, DeWald LE, King SR, Dube D, Legendre M, Nelson E, Drews KC, Gross R, Gerhardt DM, Torzewski L, Postnikova E, Liang JY, Ban B, Shetty J, Hensley LE, Jahrling PB, Olinger GG Jr, White JM, Markovitz DM. Covés-Datson EM, et al. PLoS Negl Trop Dis. 2019 Jul 29;13(7):e0007595. doi: 10.1371/journal.pntd.0007595. eCollection 2019 Jul. PLoS Negl Trop Dis. 2019. PMID: 31356611 Free PMC article.
The C-X-C chemokine IP-10 stimulates HIV-1 replication.
Lane BR, King SR, Bock PJ, Strieter RM, Coffey MJ, Markovitz DM. Lane BR, et al. Virology. 2003 Mar 1;307(1):122-34. doi: 10.1016/s0042-6822(02)00045-4. Virology. 2003. PMID: 12667820 Free article.
4,346 results