Meagher JL - Search Results

1

Engineering a therapeutic lectin by uncoupling mitogenicity from antiviral activity.

Swanson MD, Boudreaux DM, Salmon L, Chugh J, Winter HC, Meagher JL, André S, Murphy PV, Oscarson S, Roy R, King S, Kaplan MH, Goldstein IJ, Tarbet EB, Hurst BL, Smee DF, de la Fuente C, Hoffmann HH, Xue Y, Rice CM, Schols D, Garcia JV, Stuckey JA, Gabius HJ, Al-Hashimi HM, Markovitz DM. Swanson MD, et al. Among authors: meagher jl. Cell. 2015 Oct 22;163(3):746-58. doi: 10.1016/j.cell.2015.09.056. Epub 2015 Oct 22. Cell. 2015. PMID: 26496612 Free PMC article.

2

Crystal structure of banana lectin reveals a novel second sugar binding site.

Meagher JL, Winter HC, Ezell P, Goldstein IJ, Stuckey JA. Meagher JL, et al. Glycobiology. 2005 Oct;15(10):1033-42. doi: 10.1093/glycob/cwi088. Epub 2005 Jun 8. Glycobiology. 2005. PMID: 15944373

3

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

Sun H, Nikolovska-Coleska Z, Lu J, Qiu S, Yang CY, Gao W, Meagher J, Stuckey J, Wang S. Sun H, et al. J Med Chem. 2006 Dec 28;49(26):7916-20. doi: 10.1021/jm061108d. J Med Chem. 2006. PMID: 17181177

4

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, Qiu S, Tomita Y, Ueda Y, Jiang S, Krajewski K, Roller PP, Stuckey JA, Wang S. Sun H, et al. Among authors: meagher jl. J Am Chem Soc. 2007 Dec 12;129(49):15279-94. doi: 10.1021/ja074725f. Epub 2007 Nov 14. J Am Chem Soc. 2007. PMID: 17999504 Free PMC article.

5

Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Kawamoto SA, Gao W, Yi H, Qin D, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Among authors: meagher jl. Anal Biochem. 2008 Mar 1;374(1):87-98. doi: 10.1016/j.ab.2007.10.032. Epub 2007 Nov 20. Anal Biochem. 2008. PMID: 18023397

6

Interaction of a cyclic, bivalent smac mimetic with the x-linked inhibitor of apoptosis protein.

Nikolovska-Coleska Z, Meagher JL, Jiang S, Yang CY, Qiu S, Roller PP, Stuckey JA, Wang S. Nikolovska-Coleska Z, et al. Among authors: meagher jl. Biochemistry. 2008 Sep 16;47(37):9811-24. doi: 10.1021/bi800785y. Epub 2008 Aug 22. Biochemistry. 2008. PMID: 18717598 Free PMC article.

7

Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP).

Sun H, Stuckey JA, Nikolovska-Coleska Z, Qin D, Meagher JL, Qiu S, Lu J, Yang CY, Saito NG, Wang S. Sun H, et al. Among authors: meagher jl. J Med Chem. 2008 Nov 27;51(22):7169-80. doi: 10.1021/jm8006849. J Med Chem. 2008. PMID: 18954041 Free PMC article.

8

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S. Lu J, et al. Among authors: meagher jl. Cancer Res. 2008 Nov 15;68(22):9384-93. doi: 10.1158/0008-5472.CAN-08-2655. Cancer Res. 2008. PMID: 19010913 Free PMC article.

9

Structural basis for the enhanced stability of highly fluorinated proteins.

Buer BC, Meagher JL, Stuckey JA, Marsh EN. Buer BC, et al. Among authors: meagher jl. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4810-5. doi: 10.1073/pnas.1120112109. Epub 2012 Mar 12. Proc Natl Acad Sci U S A. 2012. PMID: 22411812 Free PMC article.

10

Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.

Zhou H, Chen J, Meagher JL, Yang CY, Aguilar A, Liu L, Bai L, Cong X, Cai Q, Fang X, Stuckey JA, Wang S. Zhou H, et al. Among authors: meagher jl. J Med Chem. 2012 May 24;55(10):4664-82. doi: 10.1021/jm300178u. Epub 2012 May 10. J Med Chem. 2012. PMID: 22448988 Free PMC article.

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