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RNA sensing by conventional dendritic cells is central to the development of lupus nephritis.
Celhar T, Hopkins R, Thornhill SI, De Magalhaes R, Hwang SH, Lee HY, Yasuga H, Jones LA, Casco J, Lee B, Thamboo TP, Zhou XJ, Poidinger M, Connolly JE, Wakeland EK, Fairhurst AM. Celhar T, et al. Among authors: wakeland ek. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6195-204. doi: 10.1073/pnas.1507052112. Epub 2015 Oct 28. Proc Natl Acad Sci U S A. 2015. PMID: 26512111 Free PMC article.
B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice.
Hwang SH, Lee H, Yamamoto M, Jones LA, Dayalan J, Hopkins R, Zhou XJ, Yarovinsky F, Connolly JE, Curotto de Lafaille MA, Wakeland EK, Fairhurst AM. Hwang SH, et al. Among authors: wakeland ek. J Immunol. 2012 Dec 15;189(12):5786-96. doi: 10.4049/jimmunol.1202195. Epub 2012 Nov 12. J Immunol. 2012. PMID: 23150717 Free PMC article.
Toll-Like Receptor 9 Deficiency Breaks Tolerance to RNA-Associated Antigens and Up-Regulates Toll-Like Receptor 7 Protein in Sle1 Mice.
Celhar T, Yasuga H, Lee HY, Zharkova O, Tripathi S, Thornhill SI, Lu HK, Au B, Lim LHK, Thamboo TP, Akira S, Wakeland EK, Connolly JE, Fairhurst AM. Celhar T, et al. Among authors: wakeland ek. Arthritis Rheumatol. 2018 Oct;70(10):1597-1609. doi: 10.1002/art.40535. Arthritis Rheumatol. 2018. PMID: 29687651 Free PMC article.
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus.
Subramanian S, Tus K, Li QZ, Wang A, Tian XH, Zhou J, Liang C, Bartov G, McDaniel LD, Zhou XJ, Schultz RA, Wakeland EK. Subramanian S, et al. Among authors: wakeland ek. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9970-5. doi: 10.1073/pnas.0603912103. Epub 2006 Jun 15. Proc Natl Acad Sci U S A. 2006. PMID: 16777955 Free PMC article.
Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice.
Fairhurst AM, Mathian A, Connolly JE, Wang A, Gray HF, George TA, Boudreaux CD, Zhou XJ, Li QZ, Koutouzov S, Banchereau J, Wakeland EK. Fairhurst AM, et al. Among authors: wakeland ek. Eur J Immunol. 2008 Jul;38(7):1948-60. doi: 10.1002/eji.200837925. Eur J Immunol. 2008. PMID: 18506882 Free PMC article.
Yaa autoimmune phenotypes are conferred by overexpression of TLR7.
Fairhurst AM, Hwang SH, Wang A, Tian XH, Boudreaux C, Zhou XJ, Casco J, Li QZ, Connolly JE, Wakeland EK. Fairhurst AM, et al. Among authors: wakeland ek. Eur J Immunol. 2008 Jul;38(7):1971-8. doi: 10.1002/eji.200838138. Eur J Immunol. 2008. PMID: 18521959 Free PMC article.
CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus.
Wang A, Fairhurst AM, Tus K, Subramanian S, Liu Y, Lin F, Igarashi P, Zhou XJ, Batteux F, Wong D, Wakeland EK, Mohan C. Wang A, et al. Among authors: wakeland ek. J Immunol. 2009 Apr 1;182(7):4448-58. doi: 10.4049/jimmunol.0801920. J Immunol. 2009. PMID: 19299746 Free PMC article.
229 results