Ashwell JD - Search Results

1

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor.

Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR. Wilson BA, et al. Among authors: ashwell jd. J Biomol Screen. 2016 Mar;21(3):277-89. doi: 10.1177/1087057115615518. Epub 2015 Nov 4. J Biomol Screen. 2016. PMID: 26538432 Free PMC article.

2

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.

Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ Jr, Ashwell JD. Salvador JM, et al. Among authors: ashwell jd. Nat Immunol. 2005 Apr;6(4):390-5. doi: 10.1038/ni1177. Epub 2005 Feb 27. Nat Immunol. 2005. PMID: 15735648

3

Activating p38 MAPK: new tricks for an old kinase.

Mittelstadt PR, Salvador JM, Fornace AJ Jr, Ashwell JD. Mittelstadt PR, et al. Among authors: ashwell jd. Cell Cycle. 2005 Sep;4(9):1189-92. doi: 10.4161/cc.4.9.2043. Epub 2005 Sep 20. Cell Cycle. 2005. PMID: 16103752 Review.

4

The many paths to p38 mitogen-activated protein kinase activation in the immune system.

Ashwell JD. Ashwell JD. Nat Rev Immunol. 2006 Jul;6(7):532-40. doi: 10.1038/nri1865. Nat Rev Immunol. 2006. PMID: 16799472 Review.

5

T cell receptor-mediated activation of p38{alpha} by mono-phosphorylation of the activation loop results in altered substrate specificity.

Mittelstadt PR, Yamaguchi H, Appella E, Ashwell JD. Mittelstadt PR, et al. Among authors: ashwell jd. J Biol Chem. 2009 Jun 5;284(23):15469-74. doi: 10.1074/jbc.M901004200. Epub 2009 Mar 25. J Biol Chem. 2009. PMID: 19324872 Free PMC article.

6

Counter-regulation of T cell effector function by differentially activated p38.

Alam MS, Gaida MM, Ogawa Y, Kolios AG, Lasitschka F, Ashwell JD. Alam MS, et al. Among authors: ashwell jd. J Exp Med. 2014 Jun 2;211(6):1257-70. doi: 10.1084/jem.20131917. Epub 2014 May 26. J Exp Med. 2014. PMID: 24863062 Free PMC article.

7

Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.

Alam MS, Gaida MM, Bergmann F, Lasitschka F, Giese T, Giese NA, Hackert T, Hinz U, Hussain SP, Kozlov SV, Ashwell JD. Alam MS, et al. Among authors: ashwell jd. Nat Med. 2015 Nov;21(11):1337-43. doi: 10.1038/nm.3957. Epub 2015 Oct 19. Nat Med. 2015. PMID: 26479921 Free PMC article.

8

Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.

Alam MS, Gaida MM, Debnath S, Tagad HD, Miller Jenkins LM, Appella E, Rahman MJ, Ashwell JD. Alam MS, et al. Among authors: ashwell jd. PLoS Biol. 2018 Jan 22;16(1):e2004111. doi: 10.1371/journal.pbio.2004111. eCollection 2018 Jan. PLoS Biol. 2018. PMID: 29357353 Free PMC article.

9

TNF plays a crucial role in inflammation by signaling via T cell TNFR2.

Alam MS, Otsuka S, Wong N, Abbasi A, Gaida MM, Fan Y, Meerzaman D, Ashwell JD. Alam MS, et al. Among authors: ashwell jd. Proc Natl Acad Sci U S A. 2021 Dec 14;118(50):e2109972118. doi: 10.1073/pnas.2109972118. Proc Natl Acad Sci U S A. 2021. PMID: 34873037 Free PMC article.

10

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4⁺ T cells.

Park JE, Kim TS, Zeng Y, Monnie CM, Alam MS, Zhou M, Mikolaj M, Maldarelli F, Narayan K, Ahn J, Ashwell JD, Strebel K, Lee KS. Park JE, et al. Among authors: ashwell jd. Res Sq [Preprint]. 2023 Aug 22:rs.3.rs-2924123. doi: 10.21203/rs.3.rs-2924123/v1. Res Sq. 2023. Update in: Nat Commun. 2024 Mar 5;15(1):2017. doi: 10.1038/s41467-024-46306-8 PMID: 37645926 Free PMC article. Updated. Preprint.

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