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A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition.
Stockklausner C, Raffel S, Klermund J, Bandapalli OR, Beier F, Brümmendorf TH, Bürger F, Sauer SW, Hoffmann GF, Lorenz H, Tagliaferri L, Nowak D, Hofmann WK, Buergermeister R, Kerber C, Rausch T, Korbel JO, Luke B, Trumpp A, Kulozik AE. Stockklausner C, et al. Among authors: nowak d. Aging (Albany NY). 2015 Nov;7(11):911-27. doi: 10.18632/aging.100835. Aging (Albany NY). 2015. PMID: 26546739 Free PMC article.
Detection of differential mitotic cell age in bone marrow CD34(+) cells from patients with myelodysplastic syndrome and acute leukemia by analysis of an epigenetic molecular clock DNA signature.
Mossner M, Hopfer O, Nowak D, Baldus CD, Neumann U, Kmetsch A, Benlasfer O, John T, Perka C, Thiel E, Hofmann WK. Mossner M, et al. Among authors: nowak d. Exp Hematol. 2010 Aug;38(8):661-5. doi: 10.1016/j.exphem.2010.03.022. Epub 2010 Jun 16. Exp Hematol. 2010. PMID: 20399247
Skewed X-inactivation patterns in ageing healthy and myelodysplastic haematopoiesis determined by a pyrosequencing based transcriptional clonality assay.
Mossner M, Nolte F, Hütter G, Reins J, Klaumünzer M, Nowak V, Obländer J, Ackermann K, Will S, Röhl H, Neumann U, Neumann M, Hopfer O, Baldus CD, Hofmann WK, Nowak D. Mossner M, et al. Among authors: nowak d, nowak v. J Med Genet. 2013 Feb;50(2):108-17. doi: 10.1136/jmedgenet-2012-101093. J Med Genet. 2013. PMID: 23339109
1,296 results