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Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity.
Mowbray CE, Braillard S, Speed W, Glossop PA, Whitlock GA, Gibson KR, Mills JE, Brown AD, Gardner JM, Cao Y, Hua W, Morgans GL, Feijens PB, Matheeussen A, Maes LJ. Mowbray CE, et al. J Med Chem. 2015 Dec 24;58(24):9615-24. doi: 10.1021/acs.jmedchem.5b01456. Epub 2015 Dec 4. J Med Chem. 2015. PMID: 26571076 Free article.
Small, non-peptide C5a receptor antagonists: part 1.
Blagg J, Mowbray C, Pryde DC, Salmon G, Schmid E, Fairman D, Beaumont K. Blagg J, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5601-4. doi: 10.1016/j.bmcl.2008.08.106. Epub 2008 Aug 31. Bioorg Med Chem Lett. 2008. PMID: 18809326
Discovery of a small molecule inhibitor through interference with the gp120-CD4 interaction.
Williams DH, Adam F, Fenwick DR, Fok-Seang J, Gardner I, Hay D, Jaiessh R, Middleton DS, Mowbray CE, Parkinson T, Perros M, Pickford C, Platts M, Randall A, Siddle D, Stephenson PT, Tran TD, Vuong H. Williams DH, et al. Among authors: mowbray ce. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5246-9. doi: 10.1016/j.bmcl.2009.06.080. Epub 2009 Jun 25. Bioorg Med Chem Lett. 2009. PMID: 19620004
Pyrazole NNRTIs 3: optimisation of physicochemical properties.
Mowbray CE, Corbau R, Hawes M, Jones LH, Mills JE, Perros M, Selby MD, Stupple PA, Webster R, Wood A. Mowbray CE, et al. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5603-6. doi: 10.1016/j.bmcl.2009.08.043. Epub 2009 Aug 14. Bioorg Med Chem Lett. 2009. PMID: 19717303
Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR).
Masood MA, Selby MD, Bell AS, Mansfield AC, Gardner M, Smith GF, Lane C, Kenyon-Edwards H, Osborne R, Jones RM, Liu WL, Brown CD, Clarke N, Perrucio F, Mowbray CE. Masood MA, et al. Among authors: mowbray ce. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6591-5. doi: 10.1016/j.bmcl.2011.07.114. Epub 2011 Aug 27. Bioorg Med Chem Lett. 2011. PMID: 21955944
Synthesis of novel histamine H4 receptor antagonists.
Lane CA, Hay D, Mowbray CE, Paradowski M, Selby MD, Swain NA, Williams DH. Lane CA, et al. Among authors: mowbray ce. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1156-9. doi: 10.1016/j.bmcl.2011.11.098. Epub 2011 Dec 1. Bioorg Med Chem Lett. 2012. PMID: 22189138
47 results