Nicolaou KC - Search Results

1

Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs.

Nicolaou KC, Vourloumis D, Totokotsopoulos S, Papakyriakou A, Karsunky H, Fernando H, Gavrilyuk J, Webb D, Stepan AF. Nicolaou KC, et al. ChemMedChem. 2016 Jan 5;11(1):31-7. doi: 10.1002/cmdc.201500510. Epub 2015 Nov 20. ChemMedChem. 2016. PMID: 26585829

2

Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues.

Nicolaou KC, Rhoades D, Wang Y, Totokotsopoulos S, Bai R, Hamel E. Nicolaou KC, et al. ChemMedChem. 2015 Dec;10(12):1974-9. doi: 10.1002/cmdc.201500401. Epub 2015 Oct 8. ChemMedChem. 2015. PMID: 26447977

3

Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins.

Nicolaou KC, Yin J, Mandal D, Erande RD, Klahn P, Jin M, Aujay M, Sandoval J, Gavrilyuk J, Vourloumis D. Nicolaou KC, et al. J Am Chem Soc. 2016 Feb 10;138(5):1698-708. doi: 10.1021/jacs.5b12557. Epub 2016 Feb 1. J Am Chem Soc. 2016. PMID: 26829208

4

Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds.

Nicolaou KC, Pulukuri KK, Rigol S, Heretsch P, Yu R, Grove CI, Hale CR, ElMarrouni A, Fetz V, Brönstrup M, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2016 May 25;138(20):6550-60. doi: 10.1021/jacs.6b02075. Epub 2016 May 12. J Am Chem Soc. 2016. PMID: 27171618

5

12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents.

Nicolaou KC, Rhoades D, Wang Y, Bai R, Hamel E, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2017 May 31;139(21):7318-7334. doi: 10.1021/jacs.7b02655. Epub 2017 May 17. J Am Chem Soc. 2017. PMID: 28513142

6

Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues.

Nicolaou KC, Chen P, Zhu S, Cai Q, Erande RD, Li R, Sun H, Pulukuri KK, Rigol S, Aujay M, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2017 Nov 1;139(43):15467-15478. doi: 10.1021/jacs.7b08820. Epub 2017 Oct 20. J Am Chem Soc. 2017. PMID: 29052423

7

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.

Nicolaou KC, Erande RD, Yin J, Vourloumis D, Aujay M, Sandoval J, Munneke S, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2018 Mar 14;140(10):3690-3711. doi: 10.1021/jacs.7b12692. Epub 2018 Jan 30. J Am Chem Soc. 2018. PMID: 29381062

8

Streamlined Total Synthesis of Shishijimicin A and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues thereof and Practical Syntheses of PhthNSSMe and Related Sulfenylating Reagents.

Nicolaou KC, Li R, Lu Z, Pitsinos EN, Alemany LB, Aujay M, Lee C, Sandoval J, Gavrilyuk J. Nicolaou KC, et al. J Am Chem Soc. 2018 Sep 26;140(38):12120-12136. doi: 10.1021/jacs.8b06955. Epub 2018 Sep 14. J Am Chem Soc. 2018. PMID: 30216054

9

Short Total Synthesis of Δ¹²-Prostaglandin J₂ and Related Prostaglandins. Design, Synthesis, and Biological Evaluation of Macrocyclic Δ¹²-Prostaglandin J₂ Analogues.

Nicolaou KC, Pulukuri KK, Rigol S, Peitsinis Z, Yu R, Kishigami S, Cen N, Aujay M, Sandoval J, Zepeda N, Gavrilyuk J. Nicolaou KC, et al. J Org Chem. 2019 Jan 4;84(1):365-378. doi: 10.1021/acs.joc.8b03057. Epub 2018 Dec 20. J Org Chem. 2019. PMID: 30557504

10

Design, Synthesis, and Biological Investigation of Epothilone B Analogues Featuring Lactone, Lactam, and Carbocyclic Macrocycles, Epoxide, Aziridine, and 1,1-Difluorocyclopropane and Other Fluorine Residues.

Nicolaou KC, Shelke YG, Dherange BD, Kempema A, Lin B, Gu C, Sandoval J, Hammond M, Aujay M, Gavrilyuk J. Nicolaou KC, et al. J Org Chem. 2020 Mar 6;85(5):2865-2917. doi: 10.1021/acs.joc.0c00123. Epub 2020 Feb 17. J Org Chem. 2020. PMID: 32065746

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