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Early and brain region-specific decrease of de novo cholesterol biosynthesis in Huntington's disease: A cross-validation study in Q175 knock-in mice.
Shankaran M, Di Paolo E, Leoni V, Caccia C, Ferrari Bardile C, Mohammed H, Di Donato S, Kwak S, Marchionini D, Turner S, Cattaneo E, Valenza M. Shankaran M, et al. Among authors: valenza m. Neurobiol Dis. 2017 Feb;98:66-76. doi: 10.1016/j.nbd.2016.11.013. Epub 2016 Nov 30. Neurobiol Dis. 2017. PMID: 27913290
Striatal infusion of cholesterol promotes dose-dependent behavioral benefits and exerts disease-modifying effects in Huntington's disease mice.
Birolini G, Valenza M, Di Paolo E, Vezzoli E, Talpo F, Maniezzi C, Caccia C, Leoni V, Taroni F, Bocchi VD, Conforti P, Sogne E, Petricca L, Cariulo C, Verani M, Caricasole A, Falqui A, Biella G, Cattaneo E. Birolini G, et al. Among authors: valenza m. EMBO Mol Med. 2020 Oct 7;12(10):e12519. doi: 10.15252/emmm.202012519. Epub 2020 Sep 22. EMBO Mol Med. 2020. PMID: 32959531 Free PMC article.
Insights into kinetics, release, and behavioral effects of brain-targeted hybrid nanoparticles for cholesterol delivery in Huntington's disease.
Birolini G, Valenza M, Ottonelli I, Passoni A, Favagrossa M, Duskey JT, Bombaci M, Vandelli MA, Colombo L, Bagnati R, Caccia C, Leoni V, Taroni F, Forni F, Ruozi B, Salmona M, Tosi G, Cattaneo E. Birolini G, et al. Among authors: valenza m. J Control Release. 2021 Feb 10;330:587-598. doi: 10.1016/j.jconrel.2020.12.051. Epub 2021 Jan 5. J Control Release. 2021. PMID: 33412229
Whole body cholesterol metabolism is impaired in Huntington's disease.
Leoni V, Mariotti C, Nanetti L, Salvatore E, Squitieri F, Bentivoglio AR, Bandettini di Poggio M, Piacentini S, Monza D, Valenza M, Cattaneo E, Di Donato S. Leoni V, et al. Among authors: valenza m. Neurosci Lett. 2011 May 2;494(3):245-9. doi: 10.1016/j.neulet.2011.03.025. Epub 2011 Mar 22. Neurosci Lett. 2011. PMID: 21406216
282 results