Higgs DR - Search Results

1

Multiplexed analysis of chromosome conformation at vastly improved sensitivity.

Davies JO, Telenius JM, McGowan SJ, Roberts NA, Taylor S, Higgs DR, Hughes JR. Davies JO, et al. Among authors: higgs dr. Nat Methods. 2016 Jan;13(1):74-80. doi: 10.1038/nmeth.3664. Epub 2015 Nov 23. Nat Methods. 2016. PMID: 26595209 Free PMC article.

2

De novo deletion within the telomeric region flanking the human alpha globin locus as a cause of alpha thalassaemia.

Viprakasit V, Kidd AM, Ayyub H, Horsley S, Hughes J, Higgs DR. Viprakasit V, et al. Among authors: higgs dr. Br J Haematol. 2003 Mar;120(5):867-75. doi: 10.1046/j.1365-2141.2003.04197.x. Br J Haematol. 2003. PMID: 12614224 Free article.

3

Comparative analysis of the alpha-like globin clusters in mouse, rat, and human chromosomes indicates a mechanism underlying breaks in conserved synteny.

Tufarelli C, Hardison R, Miller W, Hughes J, Clark K, Ventress N, Frischauf AM, Higgs DR. Tufarelli C, et al. Among authors: higgs dr. Genome Res. 2004 Apr;14(4):623-30. doi: 10.1101/gr.2143604. Genome Res. 2004. PMID: 15060003 Free PMC article.

4

Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2.

Anguita E, Hughes J, Heyworth C, Blobel GA, Wood WG, Higgs DR. Anguita E, et al. Among authors: higgs dr. EMBO J. 2004 Jul 21;23(14):2841-52. doi: 10.1038/sj.emboj.7600274. Epub 2004 Jun 24. EMBO J. 2004. PMID: 15215894 Free PMC article.

5

Annotation of cis-regulatory elements by identification, subclassification, and functional assessment of multispecies conserved sequences.

Hughes JR, Cheng JF, Ventress N, Prabhakar S, Clark K, Anguita E, De Gobbi M, de Jong P, Rubin E, Higgs DR. Hughes JR, et al. Among authors: higgs dr. Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9830-5. doi: 10.1073/pnas.0503401102. Epub 2005 Jul 5. Proc Natl Acad Sci U S A. 2005. PMID: 15998734 Free PMC article.

6

How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation.

Higgs DR, Vernimmen D, De Gobbi M, Anguita E, Hughes J, Buckle V, Iborra F, Garrick D, Wood WG. Higgs DR, et al. Biochem Soc Symp. 2006;(73):11-22. doi: 10.1042/bss0730011. Biochem Soc Symp. 2006. PMID: 16626283 Free article.

7

A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter.

De Gobbi M, Viprakasit V, Hughes JR, Fisher C, Buckle VJ, Ayyub H, Gibbons RJ, Vernimmen D, Yoshinaga Y, de Jong P, Cheng JF, Rubin EM, Wood WG, Bowden D, Higgs DR. De Gobbi M, et al. Among authors: higgs dr. Science. 2006 May 26;312(5777):1215-7. doi: 10.1126/science.1126431. Science. 2006. PMID: 16728641

8

Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence.

Wallace HA, Marques-Kranc F, Richardson M, Luna-Crespo F, Sharpe JA, Hughes J, Wood WG, Higgs DR, Smith AJ. Wallace HA, et al. Among authors: higgs dr. Cell. 2007 Jan 12;128(1):197-209. doi: 10.1016/j.cell.2006.11.044. Cell. 2007. PMID: 17218265 Free article.

9

Using genomics to study how chromatin influences gene expression.

Higgs DR, Vernimmen D, Hughes J, Gibbons R. Higgs DR, et al. Annu Rev Genomics Hum Genet. 2007;8:299-325. doi: 10.1146/annurev.genom.8.080706.092323. Annu Rev Genomics Hum Genet. 2007. PMID: 17506662 Review.

10

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

De Gobbi M, Anguita E, Hughes J, Sloane-Stanley JA, Sharpe JA, Koch CM, Dunham I, Gibbons RJ, Wood WG, Higgs DR. De Gobbi M, et al. Among authors: higgs dr. Blood. 2007 Dec 15;110(13):4503-10. doi: 10.1182/blood-2007-06-097964. Epub 2007 Aug 22. Blood. 2007. PMID: 17715390 Free article.

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