Romero DL - Search Results

1

Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy.

Kelly PN, Romero DL, Yang Y, Shaffer AL 3rd, Chaudhary D, Robinson S, Miao W, Rui L, Westlin WF, Kapeller R, Staudt LM. Kelly PN, et al. Among authors: romero dl. J Exp Med. 2015 Dec 14;212(13):2189-201. doi: 10.1084/jem.20151074. Epub 2015 Nov 30. J Exp Med. 2015. PMID: 26621451 Free PMC article.

2

Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders.

Chaudhary D, Robinson S, Romero DL. Chaudhary D, et al. Among authors: romero dl. J Med Chem. 2015 Jan 8;58(1):96-110. doi: 10.1021/jm5016044. Epub 2014 Dec 5. J Med Chem. 2015. PMID: 25479567 Review.

3

Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis.

Leit S, Greenwood JR, Mondal S, Carriero S, Dahlgren M, Harriman GC, Kennedy-Smith JJ, Kapeller R, Lawson JP, Romero DL, Toms AV, Shelley M, Wester RT, Westlin W, McElwee JJ, Miao W, Edmondson SD, Masse CE. Leit S, et al. Among authors: romero dl. Bioorg Med Chem Lett. 2022 Oct 1;73:128891. doi: 10.1016/j.bmcl.2022.128891. Epub 2022 Jul 13. Bioorg Med Chem Lett. 2022. PMID: 35842205

4

Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field.

Wang L, Wu Y, Deng Y, Kim B, Pierce L, Krilov G, Lupyan D, Robinson S, Dahlgren MK, Greenwood J, Romero DL, Masse C, Knight JL, Steinbrecher T, Beuming T, Damm W, Harder E, Sherman W, Brewer M, Wester R, Murcko M, Frye L, Farid R, Lin T, Mobley DL, Jorgensen WL, Berne BJ, Friesner RA, Abel R. Wang L, et al. Among authors: romero dl. J Am Chem Soc. 2015 Feb 25;137(7):2695-703. doi: 10.1021/ja512751q. Epub 2015 Feb 12. J Am Chem Soc. 2015. PMID: 25625324

5

Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders.

Gurney ME, Nugent RA, Mo X, Sindac JA, Hagen TJ, Fox D 3rd, O'Donnell JM, Zhang C, Xu Y, Zhang HT, Groppi VE, Bailie M, White RE, Romero DL, Vellekoop AS, Walker JR, Surman MD, Zhu L, Campbell RF. Gurney ME, et al. Among authors: romero dl. J Med Chem. 2019 May 23;62(10):4884-4901. doi: 10.1021/acs.jmedchem.9b00193. Epub 2019 Apr 23. J Med Chem. 2019. PMID: 31013090 Free PMC article.

6

Discovery and initial development of a novel class of antibacterials: inhibitors of Staphylococcus aureus transcription/translation.

Larsen SD, Hester MR, Craig Ruble J, Kamilar GM, Romero DL, Wakefield B, Melchior EP, Sweeney MT, Marotti KR. Larsen SD, et al. Among authors: romero dl. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6173-7. doi: 10.1016/j.bmcl.2006.09.044. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2006. PMID: 17027262

7

Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.

Genin MJ, Biles C, Keiser BJ, Poppe SM, Swaney SM, Tarpley WG, Yagi Y, Romero DL. Genin MJ, et al. Among authors: romero dl. J Med Chem. 2000 Mar 9;43(5):1034-40. doi: 10.1021/jm990383f. J Med Chem. 2000. PMID: 10715167

8

Structure-activity relationships of bioisosteres of a carboxylic acid in a novel class of bacterial translation inhibitors.

Ruble JC, Wakefield BD, Kamilar GM, Marotti KR, Melchior E, Sweeney MT, Zurenko GE, Romero DL. Ruble JC, et al. Among authors: romero dl. Bioorg Med Chem Lett. 2007 Jul 15;17(14):4040-3. doi: 10.1016/j.bmcl.2007.04.074. Epub 2007 Apr 27. Bioorg Med Chem Lett. 2007. PMID: 17561394

9

Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.

Genin MJ, Poel TJ, May PD, Kopta LA, Yagi Y, Olmsted RA, Friis JM, Voorman RL, Adams WJ, Thomas RC, Romero DL. Genin MJ, et al. Among authors: romero dl. J Med Chem. 1999 Oct 7;42(20):4140-9. doi: 10.1021/jm990051a. J Med Chem. 1999. PMID: 10514284

10

Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics.

Stiff C, Graber DR, Thorarensen A, Wakefield BD, Marotti KR, Melchior EP, Sweeney MT, Han F, Rohrer DC, Zurenko GE, Romero DL. Stiff C, et al. Among authors: romero dl. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6293-7. doi: 10.1016/j.bmcl.2007.08.041. Epub 2007 Aug 25. Bioorg Med Chem Lett. 2008. PMID: 18951783

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

44 results

Search Page

Filters