Dooley CT - Search Results

1

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.

Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Houghten RA, et al. Among authors: dooley ct. ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5. ACS Comb Sci. 2016. PMID: 26651386 Free PMC article.

2

Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library.

Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Reilley KJ, et al. Among authors: dooley ct. AAPS J. 2010 Sep;12(3):318-29. doi: 10.1208/s12248-010-9191-3. Epub 2010 Apr 27. AAPS J. 2010. PMID: 20422341 Free PMC article.

3

Use and implications of the harmonic mean model on mixtures for basic research and drug discovery.

Santos RG, Giulianotti MA, Dooley CT, Pinilla C, Appel JR, Houghten RA. Santos RG, et al. Among authors: dooley ct. ACS Comb Sci. 2011 May 9;13(3):337-44. doi: 10.1021/co100065a. Epub 2011 Mar 11. ACS Comb Sci. 2011. PMID: 21395284 Free PMC article.

4

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.

Giulianotti MA, Debevec G, Santos RG, Maida LE, Chen W, Ou L, Yu Y, Dooley CT, Houghten RA. Giulianotti MA, et al. Among authors: dooley ct. ACS Comb Sci. 2012 Sep 10;14(9):503-12. doi: 10.1021/co300060s. Epub 2012 Aug 28. ACS Comb Sci. 2012. PMID: 22913403 Free PMC article.

5

Fluorescent mu selective opioid ligands from a mixture based cyclic peptide library.

Li Y, Dooley CT, Misler JA, Debevec G, Giulianotti MA, Cazares ME, Maida L, Houghten RA. Li Y, et al. Among authors: dooley ct. ACS Comb Sci. 2012 Dec 10;14(12):673-9. doi: 10.1021/co300110t. Epub 2012 Nov 8. ACS Comb Sci. 2012. PMID: 23110623 Free PMC article.

6

Parallel Synthesis of Hexahydrodiimidazodiazepines Heterocyclic Peptidomimetics and Their in Vitro and in Vivo Activities at μ (MOR), δ (DOR), and κ (KOR) Opioid Receptors.

Eans SO, Ganno ML, Mizrachi E, Houghten RA, Dooley CT, McLaughlin JP, Nefzi A. Eans SO, et al. Among authors: dooley ct. J Med Chem. 2015 Jun 25;58(12):4905-17. doi: 10.1021/jm501637c. Epub 2015 Jun 4. J Med Chem. 2015. PMID: 25996309

7

Synthesis and biological evaluations of novel endomorphin analogues containing α-hydroxy-β-phenylalanine (AHPBA) displaying mixed μ/δ opioid receptor agonist and δ opioid receptor antagonist activities.

Hu M, Giulianotti MA, McLaughlin JP, Shao J, Debevec G, Maida LE, Geer P, Cazares M, Misler J, Li L, Dooley C, Ganno ML, Eans SO, Mizrachi E, Santos RG, Yongye AB, Houghten RA, Yu Y. Hu M, et al. Eur J Med Chem. 2015 Mar 6;92:270-81. doi: 10.1016/j.ejmech.2014.12.049. Epub 2014 Dec 29. Eur J Med Chem. 2015. PMID: 25559207

8

De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library.

Houghten RA, Dooley CT, Appel JR. Houghten RA, et al. Among authors: dooley ct. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1947-51. doi: 10.1016/j.bmcl.2004.01.090. Bioorg Med Chem Lett. 2004. PMID: 15050634

9

Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries.

Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA. Nefzi A, et al. Among authors: dooley ct. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4331-8. doi: 10.1016/j.bmcl.2006.05.053. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750366

10

In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands.

Houghten RA, Dooley CT, Appel JR. Houghten RA, et al. Among authors: dooley ct. AAPS J. 2006 May 26;8(2):E371-82. doi: 10.1007/BF02854908. AAPS J. 2006. PMID: 16796388 Free PMC article. Review.

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