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Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine Bis-piperazines.
Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Houghten RA, et al. Among authors: giulianotti ma. ACS Comb Sci. 2016 Jan 11;18(1):51-64. doi: 10.1021/acscombsci.5b00126. Epub 2016 Jan 5. ACS Comb Sci. 2016. PMID: 26651386 Free PMC article.
Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods.
Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A, Ostresh JM, Yu Y, Maggiora GM, Medina-Franco JL, Brunner D, Schneider J. Houghten RA, et al. Among authors: giulianotti ma. J Comb Chem. 2008 Jan-Feb;10(1):3-19. doi: 10.1021/cc7001205. Epub 2007 Dec 8. J Comb Chem. 2008. PMID: 18067268 No abstract available.
84 results