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Novel brain penetrant benzofuropiperidine 5-HT₆ receptor antagonists.
Sundar BG, Bailey TR, Dunn DD, Bacon ER, Salvino JM, Morton GC, Aimone LD, Zeqi H, Mathiasen JR, Dicamillo A, Huffman MJ, McKenna BA, Kopec K, Lu LD, Brown R, Qian J, Angeles T, Connors T, Spais C, Holskin B, Galinis D, Duzic E, Schaffhauser H, Rosse GC. Sundar BG, et al. Among authors: salvino jm. Bioorg Med Chem Lett. 2012 Jan 1;22(1):120-3. doi: 10.1016/j.bmcl.2011.11.050. Epub 2011 Nov 22. Bioorg Med Chem Lett. 2012. PMID: 22153937
Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.
Tripathy R, McHugh RJ, Bacon ER, Salvino JM, Morton GC, Aimone LD, Huang Z, Mathiasen JR, DiCamillo A, Huffman MJ, McKenna BA, Kopec K, Lu LD, Qian J, Angeles TS, Connors T, Spais C, Holskin B, Duzic E, Schaffhauser H, Rossé GC. Tripathy R, et al. Among authors: salvino jm. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1421-6. doi: 10.1016/j.bmcl.2011.12.026. Epub 2011 Dec 13. Bioorg Med Chem Lett. 2012. PMID: 22226656
Knowledge-based chemoinformatic approaches to drug discovery.
Ghose AK, Herbertz T, Salvino JM, Mallamo JP. Ghose AK, et al. Among authors: salvino jm. Drug Discov Today. 2006 Dec;11(23-24):1107-14. doi: 10.1016/j.drudis.2006.10.012. Epub 2006 Nov 2. Drug Discov Today. 2006. PMID: 17129830 Review.
87 results