Zhang Y - Search Results

1

Discovery of Benzo[cd]indol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation.

Xue X, Zhang Y, Liu Z, Song M, Xing Y, Xiang Q, Wang Z, Tu Z, Zhou Y, Ding K, Xu Y. Xue X, et al. Among authors: zhang y. J Med Chem. 2016 Feb 25;59(4):1565-79. doi: 10.1021/acs.jmedchem.5b01511. Epub 2016 Jan 12. J Med Chem. 2016. PMID: 26731490

2

Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation.

Zhang Y, Xue X, Jin X, Song Y, Li J, Luo X, Song M, Yan W, Song H, Xu Y. Zhang Y, et al. Eur J Med Chem. 2014 May 6;78:431-41. doi: 10.1016/j.ejmech.2014.03.065. Epub 2014 Mar 22. Eur J Med Chem. 2014. PMID: 24704616

3

Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation.

Song Y, Xue X, Wu X, Wang R, Xing Y, Yan W, Zhou Y, Qian CN, Zhang Y, Xu Y. Song Y, et al. Among authors: zhang y. Eur J Med Chem. 2016 Jun 30;116:13-26. doi: 10.1016/j.ejmech.2016.03.052. Epub 2016 Mar 21. Eur J Med Chem. 2016. PMID: 27043267

4

ROR nuclear receptors: structures, related diseases, and drug discovery.

Zhang Y, Luo XY, Wu DH, Xu Y. Zhang Y, et al. Acta Pharmacol Sin. 2015 Jan;36(1):71-87. doi: 10.1038/aps.2014.120. Epub 2014 Dec 15. Acta Pharmacol Sin. 2015. PMID: 25500868 Free PMC article. Review.

5

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer.

Wang J, Zou JX, Xue X, Cai D, Zhang Y, Duan Z, Xiang Q, Yang JC, Louie MC, Borowsky AD, Gao AC, Evans CP, Lam KS, Xu J, Kung HJ, Evans RM, Xu Y, Chen HW. Wang J, et al. Among authors: zhang y. Nat Med. 2016 May;22(5):488-96. doi: 10.1038/nm.4070. Epub 2016 Mar 28. Nat Med. 2016. PMID: 27019329 Free PMC article.

6

Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y₁ and P2Y₁₂ as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.

Lei Y, Zhang B, Liu D, Zhao J, Dai X, Gao J, Mao Q, Feng Y, Zhao J, Lin F, Duan Y, Zhang Y, Bao Z, Yang Y, Mou Y, Wang S. Lei Y, et al. Among authors: zhang b, zhang y. J Med Chem. 2020 Dec 24;63(24):15752-15772. doi: 10.1021/acs.jmedchem.0c01524. Epub 2020 Dec 12. J Med Chem. 2020. PMID: 33307675

7

Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases.

Zhang B, Nikolovska-Coleska Z, Zhang Y, Bai L, Qiu S, Yang CY, Sun H, Wang S, Wu Y. Zhang B, et al. Among authors: zhang y. J Med Chem. 2008 Dec 11;51(23):7352-5. doi: 10.1021/jm801146d. J Med Chem. 2008. PMID: 19012392 Free PMC article.

8

A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.

He Y, Guo X, Yu ZH, Wu L, Gunawan AM, Zhang Y, Dixon JE, Zhang ZY. He Y, et al. Among authors: zhang zy, zhang y. Bioorg Med Chem. 2015 Jun 15;23(12):2798-809. doi: 10.1016/j.bmc.2015.03.066. Epub 2015 Mar 31. Bioorg Med Chem. 2015. PMID: 25907364 Free PMC article.

9

Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.

Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND. Bonnefous C, et al. Among authors: zhang y. J Med Chem. 2009 May 14;52(9):3047-62. doi: 10.1021/jm900173b. J Med Chem. 2009. PMID: 19374401

10

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Cheng H, et al. Among authors: zhang y. Bioorg Med Chem. 2005 May 16;13(10):3577-85. doi: 10.1016/j.bmc.2004.12.004. Bioorg Med Chem. 2005. PMID: 15848770

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