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Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP. Mole DJ, et al. Among authors: howie se. Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11. Nat Med. 2016. PMID: 26752518 Free PMC article.
Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.
Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C. Duffin R, et al. Among authors: howie se. Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903. Science. 2016. PMID: 26989254 Free PMC article.
Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.
Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ. Gibbons MA, et al. Among authors: howie se. Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81. doi: 10.1164/rccm.201010-1719OC. Am J Respir Crit Care Med. 2011. PMID: 21680953
Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.
Richards JA, Bucsaiova M, Hesketh EE, Ventre C, Henderson NC, Simpson K, Bellamy CO, Howie SE, Anderton SM, Hughes J, Wigmore SJ. Richards JA, et al. Among authors: howie se. PLoS One. 2015 Sep 25;10(9):e0138688. doi: 10.1371/journal.pone.0138688. eCollection 2015. PLoS One. 2015. PMID: 26406765 Free PMC article.
Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells.
Crittenden S, Goepp M, Pollock J, Robb CT, Smyth DJ, Zhou Y, Andrews R, Tyrrell V, Gkikas K, Adima A, O'Connor RA, Davies L, Li XF, Yao HX, Ho GT, Zheng X, Mair A, Vermeren S, Qian BZ, Mole DJ, Gerasimidis K, Schwarze JKJ, Breyer RM, Arends MJ, O'Donnell VB, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Rossi AG, Howie SE, Yao C. Crittenden S, et al. Among authors: howie se. Sci Adv. 2021 Feb 12;7(7):eabd7954. doi: 10.1126/sciadv.abd7954. Print 2021 Feb. Sci Adv. 2021. PMID: 33579710 Free PMC article.
158 results