McPhail JA - Search Results

1

Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIIIβ with Rab11.

Fowler ML, McPhail JA, Jenkins ML, Masson GR, Rutaganira FU, Shokat KM, Williams RL, Burke JE. Fowler ML, et al. Among authors: mcphail ja. Protein Sci. 2016 Apr;25(4):826-39. doi: 10.1002/pro.2879. Epub 2016 Feb 1. Protein Sci. 2016. PMID: 26756197 Free PMC article.

2

Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ.

Rutaganira FU, Fowler ML, McPhail JA, Gelman MA, Nguyen K, Xiong A, Dornan GL, Tavshanjian B, Glenn JS, Shokat KM, Burke JE. Rutaganira FU, et al. Among authors: mcphail ja. J Med Chem. 2016 Mar 10;59(5):1830-9. doi: 10.1021/acs.jmedchem.5b01311. Epub 2016 Feb 26. J Med Chem. 2016. PMID: 26885694 Free PMC article.

3

The Molecular Basis of Aichi Virus 3A Protein Activation of Phosphatidylinositol 4 Kinase IIIβ, PI4KB, through ACBD3.

McPhail JA, Ottosen EH, Jenkins ML, Burke JE. McPhail JA, et al. Structure. 2017 Jan 3;25(1):121-131. doi: 10.1016/j.str.2016.11.016. Epub 2016 Dec 15. Structure. 2017. PMID: 27989622 Free article.

4

Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease.

Dornan GL, McPhail JA, Burke JE. Dornan GL, et al. Among authors: mcphail ja. Biochem Soc Trans. 2016 Feb;44(1):260-6. doi: 10.1042/BST20150219. Biochem Soc Trans. 2016. PMID: 26862213 Review.

5

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5.

Jenkins ML, Margaria JP, Stariha JTB, Hoffmann RM, McPhail JA, Hamelin DJ, Boulanger MJ, Hirsch E, Burke JE. Jenkins ML, et al. Among authors: mcphail ja. Nat Commun. 2018 Sep 14;9(1):3772. doi: 10.1038/s41467-018-06196-z. Nat Commun. 2018. PMID: 30217979 Free PMC article.

6

Molecular mechanisms of PI4K regulation and their involvement in viral replication.

McPhail JA, Burke JE. McPhail JA, et al. Traffic. 2023 Mar;24(3):131-145. doi: 10.1111/tra.12841. Epub 2022 Jun 2. Traffic. 2023. PMID: 35579216 Free article. Review.

7

Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.

McPhail JA, Lyoo H, Pemberton JG, Hoffmann RM, van Elst W, Strating JRPM, Jenkins ML, Stariha JTB, Powell CJ, Boulanger MJ, Balla T, van Kuppeveld FJM, Burke JE. McPhail JA, et al. EMBO Rep. 2020 Feb 5;21(2):e48441. doi: 10.15252/embr.201948441. Epub 2019 Dec 12. EMBO Rep. 2020. PMID: 31829496 Free PMC article.

8

Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections.

McPhail JA, Burke JE. McPhail JA, et al. Adv Exp Med Biol. 2020;1274:203-222. doi: 10.1007/978-3-030-50621-6_9. Adv Exp Med Biol. 2020. PMID: 32894512 Review.

9

Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors.

Fienberg S, Eyermann CJ, Arendse LB, Basarab GS, McPhail JA, Burke JE, Chibale K. Fienberg S, et al. Among authors: mcphail ja. ACS Infect Dis. 2020 Nov 13;6(11):3048-3063. doi: 10.1021/acsinfecdis.0c00566. Epub 2020 Oct 9. ACS Infect Dis. 2020. PMID: 32966036

10

Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.

Borsari C, Keles E, McPhail JA, Schaefer A, Sriramaratnam R, Goch W, Schaefer T, De Pascale M, Bal W, Gstaiger M, Burke JE, Wymann MP. Borsari C, et al. Among authors: mcphail ja. J Am Chem Soc. 2022 Apr 13;144(14):6326-6342. doi: 10.1021/jacs.1c13568. Epub 2022 Mar 30. J Am Chem Soc. 2022. PMID: 35353516 Free PMC article.

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