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Hemolysis-induced lethality involves inflammasome activation by heme.
Dutra FF, Alves LS, Rodrigues D, Fernandez PL, de Oliveira RB, Golenbock DT, Zamboni DS, Bozza MT. Dutra FF, et al. Among authors: rodrigues d. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4110-8. doi: 10.1073/pnas.1405023111. Epub 2014 Sep 15. Proc Natl Acad Sci U S A. 2014. PMID: 25225402 Free PMC article.
Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
Fortes GB, Alves LS, de Oliveira R, Dutra FF, Rodrigues D, Fernandez PL, Souto-Padron T, De Rosa MJ, Kelliher M, Golenbock D, Chan FK, Bozza MT. Fortes GB, et al. Among authors: rodrigues d. Blood. 2012 Mar 8;119(10):2368-75. doi: 10.1182/blood-2011-08-375303. Epub 2012 Jan 18. Blood. 2012. PMID: 22262768 Free PMC article.
Chloroquine inhibits pro-inflammatory effects of heme on macrophages and invivo.
Silva RCMC, Tan L, Rodrigues DA, Prestes EB, Gomes CP, Gama AM, Oliveira PL, Paiva CN, Manoury B, Bozza MT. Silva RCMC, et al. Free Radic Biol Med. 2021 Sep;173:104-116. doi: 10.1016/j.freeradbiomed.2021.07.028. Epub 2021 Jul 22. Free Radic Biol Med. 2021. PMID: 34303829 Free article.
A Nutritional Strategy Based on Multiple Components for Glycemic Control in Type 2 Diabetes: A Multicenter Randomized Controlled Clinical Trial.
Bersch-Ferreira AC, Machado RHV, Oliveira JS, Santos RHN, da Silva LR, Mota LGS, Pagano R, Sady ERR, Miyada DHK, Miranda TA, Martins PN, de Almeida JC, Marchioni DML, Lara EMS, Gherardi-Donato ECS, Quinhoneiro D, de Souza SR, Porto AQ, Busnello FM, Bauer J, Dos Santos TA, Ferreira DC, Valente MAS, Sahade V, Curvello-Silva KL, Ferreira LG, Rodrigues DAC, Bressan J, Campos TN, Arbex AK, Sanchez JG, Weber B, Cavalcanti AB, Marcadenti A. Bersch-Ferreira AC, et al. Among authors: rodrigues dac. Nutrients. 2024 Nov 10;16(22):3849. doi: 10.3390/nu16223849. Nutrients. 2024. PMID: 39599635 Free PMC article. Clinical Trial.
1,818 results