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Page 1
Pharmacological characterization of the first in class clinical candidate PF-05190457: a selective ghrelin receptor competitive antagonist with inverse agonism that increases vagal afferent firing and glucose-dependent insulin secretion ex vivo.
Kong J, Chuddy J, Stock IA, Loria PM, Straub SV, Vage C, Cameron KO, Bhattacharya SK, Lapham K, McClure KF, Zhang Y, Jackson VM. Kong J, et al. Among authors: jackson vm. Br J Pharmacol. 2016 May;173(9):1452-64. doi: 10.1111/bph.13439. Epub 2016 Mar 17. Br J Pharmacol. 2016. PMID: 26784385 Free PMC article.
Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.
Bhattacharya SK, Andrews K, Beveridge R, Cameron KO, Chen C, Dunn M, Fernando D, Gao H, Hepworth D, Jackson VM, Khot V, Kong J, Kosa RE, Lapham K, Loria PM, Londregan AT, McClure KF, Orr ST, Patel J, Rose C, Saenz J, Stock IA, Storer G, VanVolkenburg M, Vrieze D, Wang G, Xiao J, Zhang Y. Bhattacharya SK, et al. Among authors: jackson vm. ACS Med Chem Lett. 2014 Feb 24;5(5):474-9. doi: 10.1021/ml400473x. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900864 Free PMC article.
A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
Griffith DA, Edmonds DJ, Fortin JP, Kalgutkar AS, Kuzmiski JB, Loria PM, Saxena AR, Bagley SW, Buckeridge C, Curto JM, Derksen DR, Dias JM, Griffor MC, Han S, Jackson VM, Landis MS, Lettiere D, Limberakis C, Liu Y, Mathiowetz AM, Patel JC, Piotrowski DW, Price DA, Ruggeri RB, Tess DA. Griffith DA, et al. Among authors: jackson vm. J Med Chem. 2022 Jun 23;65(12):8208-8226. doi: 10.1021/acs.jmedchem.1c01856. Epub 2022 Jun 1. J Med Chem. 2022. PMID: 35647711 Free PMC article.
Leptin potentiates the anti-obesity effects of rimonabant.
Boustany-Kari CM, Jackson VM, Gibbons CP, Swick AG. Boustany-Kari CM, et al. Among authors: jackson vm. Eur J Pharmacol. 2011 May 11;658(2-3):270-6. doi: 10.1016/j.ejphar.2011.02.021. Epub 2011 Mar 1. Eur J Pharmacol. 2011. PMID: 21371466
Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass.
Lumsden AL, Martin AM, Sun EW, Schober G, Isaacs NJ, Pezos N, Wattchow DA, de Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due SL, Rayner CK, Nguyen NQ, Liou AP, Jackson VM, Young RL, Keating DJ. Lumsden AL, et al. Among authors: jackson vm. Nutrients. 2019 Jan 22;11(2):234. doi: 10.3390/nu11020234. Nutrients. 2019. PMID: 30678223 Free PMC article.
A Gut-Intrinsic Melanocortin Signaling Complex Augments L-Cell Secretion in Humans.
Sun EW, Iepsen EW, Pezos N, Lumsden AL, Martin AM, Schober G, Isaacs NJ, Rayner CK, Nguyen NQ, de Fontgalland D, Rabbitt P, Hollington P, Wattchow DA, Hansen T, Holm JC, Liou AP, Jackson VM, Torekov SS, Young RL, Keating DJ. Sun EW, et al. Among authors: jackson vm. Gastroenterology. 2021 Aug;161(2):536-547.e2. doi: 10.1053/j.gastro.2021.04.014. Epub 2021 Apr 20. Gastroenterology. 2021. PMID: 33848536
Augmented capacity for peripheral serotonin release in human obesity.
Young RL, Lumsden AL, Martin AM, Schober G, Pezos N, Thazhath SS, Isaacs NJ, Cvijanovic N, Sun EWL, Wu T, Rayner CK, Nguyen NQ, Fontgalland D, Rabbitt P, Hollington P, Sposato L, Due SL, Wattchow DA, Liou AP, Jackson VM, Keating DJ. Young RL, et al. Among authors: jackson vm. Int J Obes (Lond). 2018 Nov;42(11):1880-1889. doi: 10.1038/s41366-018-0047-8. Epub 2018 Mar 1. Int J Obes (Lond). 2018. PMID: 29568107
33 results