Fang L - Search Results

1

H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass.

Fang L, Zhang J, Zhang H, Yang X, Jin X, Zhang L, Skalnik DG, Jin Y, Zhang Y, Huang X, Li J, Wong J. Fang L, et al. Stem Cells. 2016 Mar;34(3):565-80. doi: 10.1002/stem.2250. Epub 2016 Jan 19. Stem Cells. 2016. PMID: 26785054

2

A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation.

Fang L, Zhang L, Wei W, Jin X, Wang P, Tong Y, Li J, Du JX, Wong J. Fang L, et al. Mol Cell. 2014 Aug 21;55(4):537-51. doi: 10.1016/j.molcel.2014.06.018. Epub 2014 Jul 17. Mol Cell. 2014. PMID: 25042802 Free article.

3

PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1.

Shi G, Wu M, Fang L, Yu F, Cheng S, Li J, Du JX, Wong J. Shi G, et al. Among authors: fang l. J Biol Chem. 2014 Oct 24;289(43):29691-700. doi: 10.1074/jbc.M114.571653. Epub 2014 Sep 9. J Biol Chem. 2014. PMID: 25204660 Free PMC article.

4

Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.

Jia Y, Li P, Fang L, Zhu H, Xu L, Cheng H, Zhang J, Li F, Feng Y, Li Y, Li J, Wang R, Du JX, Li J, Chen T, Ji H, Han J, Yu W, Wu Q, Wong J. Jia Y, et al. Among authors: fang l. Cell Discov. 2016 Apr 12;2:16007. doi: 10.1038/celldisc.2016.7. eCollection 2016. Cell Discov. 2016. PMID: 27462454 Free PMC article.

5

SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.

Fang L, Teng H, Wang Y, Liao G, Weng L, Li Y, Wang X, Jin J, Jiao C, Chen L, Peng X, Chen J, Yang Y, Fang H, Han D, Li C, Jin X, Zhang S, Liu Z, Liu M, Wei Q, Liao L, Ge X, Zhao B, Zhou D, Qin HL, Zhou J, Wang P. Fang L, et al. Among authors: fang h. Cancer Cell. 2018 Jul 9;34(1):103-118.e9. doi: 10.1016/j.ccell.2018.06.002. Epub 2018 Jun 28. Cancer Cell. 2018. PMID: 30008322 Free article.

6

AKT drives SOX2 overexpression and cancer cell stemness in esophageal cancer by protecting SOX2 from UBR5-mediated degradation.

Wang Z, Kang L, Zhang H, Huang Y, Fang L, Li M, Brown PJ, Arrowsmith CH, Li J, Wong J. Wang Z, et al. Among authors: fang l. Oncogene. 2019 Jun;38(26):5250-5264. doi: 10.1038/s41388-019-0790-x. Epub 2019 Mar 20. Oncogene. 2019. PMID: 30894683

7

PI3K/AKT inhibition reverses R-CHOP resistance by destabilizing SOX2 in diffuse large B cell lymphoma.

Chen J, Ge X, Zhang W, Ding P, Du Y, Wang Q, Li L, Fang L, Sun Y, Zhang P, Zhou Y, Zhang L, Lv X, Li L, Zhang X, Zhang Q, Xue K, Gu H, Lei Q, Wong J, Hu W. Chen J, et al. Among authors: fang l. Theranostics. 2020 Feb 10;10(7):3151-3163. doi: 10.7150/thno.41362. eCollection 2020. Theranostics. 2020. PMID: 32194860 Free PMC article.

8

An acetylation-enhanced interaction between transcription factor Sox2 and the steroid receptor coactivators facilitates Sox2 transcriptional activity and function.

Huang Y, Duan X, Wang Z, Sun Y, Guan Q, Kang L, Zhang Q, Fang L, Li J, Wong J. Huang Y, et al. Among authors: fang l. J Biol Chem. 2021 Dec;297(6):101389. doi: 10.1016/j.jbc.2021.101389. Epub 2021 Nov 8. J Biol Chem. 2021. PMID: 34762910 Free PMC article.

9

AMPK Promotes SPOP-Mediated NANOG Degradation to Regulate Prostate Cancer Cell Stemness.

Wang X, Jin J, Wan F, Zhao L, Chu H, Chen C, Liao G, Liu J, Yu Y, Teng H, Fang L, Jiang C, Pan W, Xie X, Li J, Lu X, Jiang X, Ge X, Ye D, Wang P. Wang X, et al. Among authors: fang l. Dev Cell. 2019 Feb 11;48(3):345-360.e7. doi: 10.1016/j.devcel.2018.11.033. Epub 2018 Dec 27. Dev Cell. 2019. PMID: 30595535 Free PMC article.

10

p38 inhibition provides anti-DNA virus immunity by regulation of USP21 phosphorylation and STING activation.

Chen Y, Wang L, Jin J, Luan Y, Chen C, Li Y, Chu H, Wang X, Liao G, Yu Y, Teng H, Wang Y, Pan W, Fang L, Liao L, Jiang Z, Ge X, Li B, Wang P. Chen Y, et al. Among authors: fang l. J Exp Med. 2017 Apr 3;214(4):991-1010. doi: 10.1084/jem.20161387. Epub 2017 Mar 2. J Exp Med. 2017. PMID: 28254948 Free PMC article.

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