Dymock B - Search Results

1

Predicting chemotherapeutic drug combinations through gene network profiling.

Nguyen TT, Chua JK, Seah KS, Koo SH, Yee JY, Yang EG, Lim KK, Pang SY, Yuen A, Zhang L, Ang WH, Dymock B, Lee EJ, Chen ES. Nguyen TT, et al. Among authors: dymock b. Sci Rep. 2016 Jan 21;6:18658. doi: 10.1038/srep18658. Sci Rep. 2016. PMID: 26791325 Free PMC article.

2

Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast.

Lim KK, Ong TY, Tan YR, Yang EG, Ren B, Seah KS, Yang Z, Tan TS, Dymock BW, Chen ES. Lim KK, et al. Among authors: dymock bw. Sci Rep. 2015 Sep 15;5:14064. doi: 10.1038/srep14064. Sci Rep. 2015. PMID: 26369364 Free PMC article.

3

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling.

Seah KS, Loh JY, Nguyen TTT, Tan HL, Hutchinson PE, Lim KK, Dymock BW, Long YC, Lee EJD, Shen HM, Chen ES. Seah KS, et al. Exp Cell Res. 2018 Sep 15;370(2):283-291. doi: 10.1016/j.yexcr.2018.06.029. Epub 2018 Jun 28. Exp Cell Res. 2018. PMID: 29959912

4

Selective JAK inhibitors.

Dymock BW, Yang EG, Chu-Farseeva Y, Yao L. Dymock BW, et al. Future Med Chem. 2014;6(12):1439-71. doi: 10.4155/fmc.14.92. Future Med Chem. 2014. PMID: 25329199 Review.

5

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines.

Yang EG, Mustafa N, Tan EC, Poulsen A, Ramanujulu PM, Chng WJ, Yen JJ, Dymock BW. Yang EG, et al. J Med Chem. 2016 Sep 22;59(18):8233-62. doi: 10.1021/acs.jmedchem.6b00157. Epub 2016 Sep 8. J Med Chem. 2016. PMID: 27541357

6

Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131).

See CS, Kitagawa M, Liao PJ, Lee KH, Wong J, Lee SH, Dymock BW. See CS, et al. Eur J Med Chem. 2018 Aug 5;156:344-367. doi: 10.1016/j.ejmech.2018.07.011. Epub 2018 Jul 7. Eur J Med Chem. 2018. PMID: 30015072

7

The rise of epigenetic drug discovery.

Dymock BW. Dymock BW. Future Med Chem. 2016 Sep;8(13):1523-4. doi: 10.4155/fmc-2016-0158. Future Med Chem. 2016. PMID: 27603715 No abstract available.

8

Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer.

See CS, Kitagawa M, Liao PJ, Lee KH, Wong J, Lee SH, Dymock BW. See CS, et al. Among authors: dymock bw. Bioorg Med Chem Lett. 2019 Jan 15;29(2):216-219. doi: 10.1016/j.bmcl.2018.11.053. Epub 2018 Nov 27. Bioorg Med Chem Lett. 2019. PMID: 30503634

9

Hydrogen sulfide promotes adipogenesis in 3T3L1 cells.

Tsai CY, Peh MT, Feng W, Dymock BW, Moore PK. Tsai CY, et al. PLoS One. 2015 Mar 30;10(3):e0119511. doi: 10.1371/journal.pone.0119511. eCollection 2015. PLoS One. 2015. PMID: 25822632 Free PMC article.

10

Discovery of a potent histone deacetylase (HDAC) 3/6 selective dual inhibitor.

Soumyanarayanan U, Ramanujulu PM, Mustafa N, Haider S, Fang Nee AH, Tong JX, Tan KSW, Chng WJ, Dymock BW. Soumyanarayanan U, et al. Among authors: dymock bw. Eur J Med Chem. 2019 Dec 15;184:111755. doi: 10.1016/j.ejmech.2019.111755. Epub 2019 Oct 7. Eur J Med Chem. 2019. PMID: 31627059

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