Furet P - Search Results

1

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.

Honda A, Harrington E, Cornella-Taracido I, Furet P, Knapp MS, Glick M, Triantafellow E, Dowdle WE, Wiedershain D, Maniara W, Moore C, Finan PM, Hamann LG, Firestone B, Murphy LO, Keaney EP. Honda A, et al. Among authors: furet p. ACS Med Chem Lett. 2015 Nov 13;7(1):72-6. doi: 10.1021/acsmedchemlett.5b00335. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819669 Free PMC article.

2

Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.

Traxler P, Bold G, Frei J, Lang M, Lydon N, Mett H, Buchdunger E, Meyer T, Mueller M, Furet P. Traxler P, et al. Among authors: furet p. J Med Chem. 1997 Oct 24;40(22):3601-16. doi: 10.1021/jm970124v. J Med Chem. 1997. PMID: 9357527

3

2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.

Imbach P, Capraro HG, Furet P, Mett H, Meyer T, Zimmermann J. Imbach P, et al. Among authors: furet p. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. doi: 10.1016/s0960-894x(98)00691-x. Bioorg Med Chem Lett. 1999. PMID: 9990463

4

A new structural class of selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome.

García-Echeverría C, Imbach P, France D, Fürst P, Lang M, Noorani AM, Scholz D, Zimmermann J, Furet P. García-Echeverría C, et al. Among authors: furet p. Bioorg Med Chem Lett. 2001 May 21;11(10):1317-9. doi: 10.1016/s0960-894x(01)00205-0. Bioorg Med Chem Lett. 2001. PMID: 11392545

5

Discovery of a potent and selective protein kinase CK2 inhibitor by high-throughput docking.

Vangrevelinghe E, Zimmermann K, Schoepfer J, Portmann R, Fabbro D, Furet P. Vangrevelinghe E, et al. Among authors: furet p. J Med Chem. 2003 Jun 19;46(13):2656-62. doi: 10.1021/jm030827e. J Med Chem. 2003. PMID: 12801229

6

Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching.

Furet P, Bold G, Hofmann F, Manley P, Meyer T, Altmann KH. Furet P, et al. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2967-71. doi: 10.1016/s0960-894x(03)00626-7. Bioorg Med Chem Lett. 2003. PMID: 12941313

7

Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.

Furet P, Imbach P, Noorani M, Koeppler J, Laumen K, Lang M, Guagnano V, Fuerst P, Roesel J, Zimmermann J, García-Echeverría C. Furet P, et al. J Med Chem. 2004 Sep 23;47(20):4810-3. doi: 10.1021/jm049660v. J Med Chem. 2004. PMID: 15369383 Free article.

8

Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Imbach P, Lang M, García-Echeverría C, Guagnano V, Noorani M, Roesel J, Bitsch F, Rihs G, Furet P. Imbach P, et al. Among authors: furet p. Bioorg Med Chem Lett. 2007 Jan 15;17(2):358-62. doi: 10.1016/j.bmcl.2006.10.047. Epub 2006 Oct 24. Bioorg Med Chem Lett. 2007. PMID: 17095212

9

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity.

Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, Brachmann S, Chène P, De Pover A, Schoemaker K, Fabbro D, Gabriel D, Simonen M, Murphy L, Finan P, Sellers W, García-Echeverría C. Maira SM, et al. Among authors: furet p. Mol Cancer Ther. 2008 Jul;7(7):1851-63. doi: 10.1158/1535-7163.MCT-08-0017. Epub 2008 Jul 7. Mol Cancer Ther. 2008. PMID: 18606717

10

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors.

Gerspacher M, Furet P, Pissot-Soldermann C, Gaul C, Holzer P, Vangrevelinghe E, Lang M, Erdmann D, Radimerski T, Regnier CH, Chene P, De Pover A, Hofmann F, Baffert F, Buhl T, Aichholz R, Blasco F, Endres R, Trappe J, Drueckes P. Gerspacher M, et al. Among authors: furet p. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1724-7. doi: 10.1016/j.bmcl.2010.01.069. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20138510

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