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Ki-67 is required for maintenance of cancer stem cells but not cell proliferation.
Cidado J, Wong HY, Rosen DM, Cimino-Mathews A, Garay JP, Fessler AG, Rasheed ZA, Hicks J, Cochran RL, Croessmann S, Zabransky DJ, Mohseni M, Beaver JA, Chu D, Cravero K, Christenson ES, Medford A, Mattox A, De Marzo AM, Argani P, Chawla A, Hurley PJ, Lauring J, Park BH. Cidado J, et al. Among authors: mohseni m. Oncotarget. 2016 Feb 2;7(5):6281-93. doi: 10.18632/oncotarget.7057. Oncotarget. 2016. PMID: 26823390 Free PMC article.
Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.
Wang GM, Wong HY, Konishi H, Blair BG, Abukhdeir AM, Gustin JP, Rosen DM, Denmeade SR, Rasheed Z, Matsui W, Garay JP, Mohseni M, Higgins MJ, Cidado J, Jelovac D, Croessmann S, Cochran RL, Karnan S, Konishi Y, Ota A, Hosokawa Y, Argani P, Lauring J, Park BH. Wang GM, et al. Among authors: mohseni m. Cancer Res. 2013 Jun 1;73(11):3248-61. doi: 10.1158/0008-5472.CAN-12-1578. Epub 2013 Apr 11. Cancer Res. 2013. PMID: 23580570 Free PMC article.
A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations.
Blair BG, Wu X, Zahari MS, Mohseni M, Cidado J, Wong HY, Beaver JA, Cochran RL, Zabransky DJ, Croessmann S, Chu D, Toro PV, Cravero K, Pandey A, Park BH. Blair BG, et al. Among authors: mohseni m. Proteomics. 2015 Jan;15(2-3):318-26. doi: 10.1002/pmic.201400342. Epub 2014 Dec 28. Proteomics. 2015. PMID: 25367220 Free PMC article.
MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers.
Mohseni M, Cidado J, Croessmann S, Cravero K, Cimino-Mathews A, Wong HY, Scharpf R, Zabransky DJ, Abukhdeir AM, Garay JP, Wang GM, Beaver JA, Cochran RL, Blair BG, Rosen DM, Erlanger B, Argani P, Hurley PJ, Lauring J, Park BH. Mohseni M, et al. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17606-11. doi: 10.1073/pnas.1408650111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422431 Free PMC article.
NDRG1 links p53 with proliferation-mediated centrosome homeostasis and genome stability.
Croessmann S, Wong HY, Zabransky DJ, Chu D, Mendonca J, Sharma A, Mohseni M, Rosen DM, Scharpf RB, Cidado J, Cochran RL, Parsons HA, Dalton WB, Erlanger B, Button B, Cravero K, Kyker-Snowman K, Beaver JA, Kachhap S, Hurley PJ, Lauring J, Park BH. Croessmann S, et al. Among authors: mohseni m. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11583-8. doi: 10.1073/pnas.1503683112. Epub 2015 Aug 31. Proc Natl Acad Sci U S A. 2015. PMID: 26324937 Free PMC article.
Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Gustin JP, Karakas B, Weiss MB, Abukhdeir AM, Lauring J, Garay JP, Cosgrove D, Tamaki A, Konishi H, Konishi Y, Mohseni M, Wang G, Rosen DM, Denmeade SR, Higgins MJ, Vitolo MI, Bachman KE, Park BH. Gustin JP, et al. Among authors: mohseni m. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2835-40. doi: 10.1073/pnas.0813351106. Epub 2009 Feb 5. Proc Natl Acad Sci U S A. 2009. PMID: 19196980 Free PMC article.
PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells.
Higgins MJ, Beaver JA, Wong HY, Gustin JP, Lauring JD, Garay JP, Konishi H, Mohseni M, Wang GM, Cidado J, Jelovac D, Cosgrove DP, Tamaki A, Abukhdeir AM, Park BH. Higgins MJ, et al. Among authors: mohseni m. Cancer Biol Ther. 2011 Feb 1;11(3):358-67. doi: 10.4161/cbt.11.3.14227. Epub 2011 Feb 1. Cancer Biol Ther. 2011. PMID: 21124076 Free PMC article.
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.
Konishi H, Mohseni M, Tamaki A, Garay JP, Croessmann S, Karnan S, Ota A, Wong HY, Konishi Y, Karakas B, Tahir K, Abukhdeir AM, Gustin JP, Cidado J, Wang GM, Cosgrove D, Cochran R, Jelovac D, Higgins MJ, Arena S, Hawkins L, Lauring J, Gross AL, Heaphy CM, Hosokawa Y, Gabrielson E, Meeker AK, Visvanathan K, Argani P, Bachman KE, Park BH. Konishi H, et al. Among authors: mohseni m. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17773-8. doi: 10.1073/pnas.1110969108. Epub 2011 Oct 10. Proc Natl Acad Sci U S A. 2011. PMID: 21987798 Free PMC article.
The growth response to androgen receptor signaling in ERα-negative human breast cells is dependent on p21 and mediated by MAPK activation.
Garay JP, Karakas B, Abukhdeir AM, Cosgrove DP, Gustin JP, Higgins MJ, Konishi H, Konishi Y, Lauring J, Mohseni M, Wang GM, Jelovac D, Weeraratna A, Sherman Baust CA, Morin PJ, Toubaji A, Meeker A, De Marzo AM, Lewis G, Subhawong A, Argani P, Park BH. Garay JP, et al. Among authors: mohseni m. Breast Cancer Res. 2012 Feb 9;14(1):R27. doi: 10.1186/bcr3112. Breast Cancer Res. 2012. PMID: 22321971 Free PMC article.
726 results