Fraser JS - Search Results

1

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.

Cimermancic P, Weinkam P, Rettenmaier TJ, Bichmann L, Keedy DA, Woldeyes RA, Schneidman-Duhovny D, Demerdash ON, Mitchell JC, Wells JA, Fraser JS, Sali A. Cimermancic P, et al. Among authors: fraser js. J Mol Biol. 2016 Feb 22;428(4):709-719. doi: 10.1016/j.jmb.2016.01.029. Epub 2016 Feb 5. J Mol Biol. 2016. PMID: 26854760 Free PMC article.

2

Crystal cryocooling distorts conformational heterogeneity in a model Michaelis complex of DHFR.

Keedy DA, van den Bedem H, Sivak DA, Petsko GA, Ringe D, Wilson MA, Fraser JS. Keedy DA, et al. Among authors: fraser js. Structure. 2014 Jun 10;22(6):899-910. doi: 10.1016/j.str.2014.04.016. Epub 2014 May 29. Structure. 2014. PMID: 24882744 Free PMC article.

3

E pluribus unum, no more: from one crystal, many conformations.

Woldeyes RA, Sivak DA, Fraser JS. Woldeyes RA, et al. Among authors: fraser js. Curr Opin Struct Biol. 2014 Oct;28:56-62. doi: 10.1016/j.sbi.2014.07.005. Epub 2014 Aug 9. Curr Opin Struct Biol. 2014. PMID: 25113271 Free PMC article. Review.

4

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.

Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA. Williams BB, et al. Among authors: fraser js. Cell Host Microbe. 2014 Oct 8;16(4):495-503. doi: 10.1016/j.chom.2014.09.001. Epub 2014 Sep 25. Cell Host Microbe. 2014. PMID: 25263219 Free PMC article.

5

Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.

Dellus-Gur E, Elias M, Caselli E, Prati F, Salverda ML, de Visser JA, Fraser JS, Tawfik DS. Dellus-Gur E, et al. Among authors: fraser js. J Mol Biol. 2015 Jul 17;427(14):2396-409. doi: 10.1016/j.jmb.2015.05.011. Epub 2015 May 22. J Mol Biol. 2015. PMID: 26004540 Free PMC article.

6

One Crystal, Two Temperatures: Cryocooling Penalties Alter Ligand Binding to Transient Protein Sites.

Fischer M, Shoichet BK, Fraser JS. Fischer M, et al. Among authors: fraser js. Chembiochem. 2015 Jul 27;16(11):1560-4. doi: 10.1002/cbic.201500196. Epub 2015 Jun 15. Chembiochem. 2015. PMID: 26032594 Free PMC article.

7

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography.

Keedy DA, Kenner LR, Warkentin M, Woldeyes RA, Hopkins JB, Thompson MC, Brewster AS, Van Benschoten AH, Baxter EL, Uervirojnangkoorn M, McPhillips SE, Song J, Alonso-Mori R, Holton JM, Weis WI, Brunger AT, Soltis SM, Lemke H, Gonzalez A, Sauter NK, Cohen AE, van den Bedem H, Thorne RE, Fraser JS. Keedy DA, et al. Among authors: fraser js. Elife. 2015 Sep 30;4:e07574. doi: 10.7554/eLife.07574. Elife. 2015. PMID: 26422513 Free PMC article.

8

Exposing Hidden Alternative Backbone Conformations in X-ray Crystallography Using qFit.

Keedy DA, Fraser JS, van den Bedem H. Keedy DA, et al. Among authors: fraser js. PLoS Comput Biol. 2015 Oct 27;11(10):e1004507. doi: 10.1371/journal.pcbi.1004507. eCollection 2015 Oct. PLoS Comput Biol. 2015. PMID: 26506617 Free PMC article.

9

High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.

Thomaston JL, Alfonso-Prieto M, Woldeyes RA, Fraser JS, Klein ML, Fiorin G, DeGrado WF. Thomaston JL, et al. Among authors: fraser js. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14260-5. doi: 10.1073/pnas.1518493112. Epub 2015 Nov 2. Proc Natl Acad Sci U S A. 2015. PMID: 26578770 Free PMC article.

10

High-density grids for efficient data collection from multiple crystals.

Baxter EL, Aguila L, Alonso-Mori R, Barnes CO, Bonagura CA, Brehmer W, Brunger AT, Calero G, Caradoc-Davies TT, Chatterjee R, Degrado WF, Fraser JS, Ibrahim M, Kern J, Kobilka BK, Kruse AC, Larsson KM, Lemke HT, Lyubimov AY, Manglik A, McPhillips SE, Norgren E, Pang SS, Soltis SM, Song J, Thomaston J, Tsai Y, Weis WI, Woldeyes RA, Yachandra V, Yano J, Zouni A, Cohen AE. Baxter EL, et al. Among authors: fraser js. Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):2-11. doi: 10.1107/S2059798315020847. Epub 2016 Jan 1. Acta Crystallogr D Struct Biol. 2016. PMID: 26894529 Free PMC article.

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