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Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells.
Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF. Withers DR, et al. Among authors: dutton ee. Nat Med. 2016 Mar;22(3):319-23. doi: 10.1038/nm.4046. Epub 2016 Feb 15. Nat Med. 2016. PMID: 26878233 Free PMC article.
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
Melo-Gonzalez F, Kammoun H, Evren E, Dutton EE, Papadopoulou M, Bradford BM, Tanes C, Fardus-Reid F, Swann JR, Bittinger K, Mabbott NA, Vallance BA, Willinger T, Withers DR, Hepworth MR. Melo-Gonzalez F, et al. Among authors: dutton ee. J Exp Med. 2019 Apr 1;216(4):728-742. doi: 10.1084/jem.20180871. Epub 2019 Feb 27. J Exp Med. 2019. PMID: 30814299 Free PMC article.
Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1.
Jeffery HC, van Wilgenburg B, Kurioka A, Parekh K, Stirling K, Roberts S, Dutton EE, Hunter S, Geh D, Braitch MK, Rajanayagam J, Iqbal T, Pinkney T, Brown R, Withers DR, Adams DH, Klenerman P, Oo YH. Jeffery HC, et al. Among authors: dutton ee. J Hepatol. 2016 May;64(5):1118-1127. doi: 10.1016/j.jhep.2015.12.017. Epub 2015 Dec 29. J Hepatol. 2016. PMID: 26743076 Free PMC article.
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