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T-cell epitope conservation across allergen species is a major determinant of immunogenicity.
Westernberg L, Schulten V, Greenbaum JA, Natali S, Tripple V, McKinney DM, Frazier A, Hofer H, Wallner M, Sallusto F, Sette A, Peters B. Westernberg L, et al. Among authors: mckinney dm. J Allergy Clin Immunol. 2016 Aug;138(2):571-578.e7. doi: 10.1016/j.jaci.2015.11.034. Epub 2016 Feb 13. J Allergy Clin Immunol. 2016. PMID: 26883464 Free PMC article.
T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts.
Oseroff C, Sidney J, Vita R, Tripple V, McKinney DM, Southwood S, Brodie TM, Sallusto F, Grey H, Alam R, Broide D, Greenbaum JA, Kolla R, Peters B, Sette A. Oseroff C, et al. Among authors: mckinney dm. J Immunol. 2012 Aug 15;189(4):1800-11. doi: 10.4049/jimmunol.1200850. Epub 2012 Jul 11. J Immunol. 2012. PMID: 22786768 Free PMC article.
Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals.
Schulten V, Greenbaum JA, Hauser M, McKinney DM, Sidney J, Kolla R, Lindestam Arlehamn CS, Oseroff C, Alam R, Broide DH, Ferreira F, Grey HM, Sette A, Peters B. Schulten V, et al. Among authors: mckinney dm. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3459-64. doi: 10.1073/pnas.1300512110. Epub 2013 Feb 11. Proc Natl Acad Sci U S A. 2013. PMID: 23401558 Free PMC article.
Molecular determinants of T cell epitope recognition to the common Timothy grass allergen.
Oseroff C, Sidney J, Kotturi MF, Kolla R, Alam R, Broide DH, Wasserman SI, Weiskopf D, McKinney DM, Chung JL, Petersen A, Grey H, Peters B, Sette A. Oseroff C, et al. Among authors: mckinney dm. J Immunol. 2010 Jul 15;185(2):943-55. doi: 10.4049/jimmunol.1000405. Epub 2010 Jun 16. J Immunol. 2010. PMID: 20554959 Free PMC article.
Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ).
Arlehamn CS, Sidney J, Henderson R, Greenbaum JA, James EA, Moutaftsi M, Coler R, McKinney DM, Park D, Taplitz R, Kwok WW, Grey H, Peters B, Sette A. Arlehamn CS, et al. Among authors: mckinney dm. J Immunol. 2012 May 15;188(10):5020-31. doi: 10.4049/jimmunol.1103556. Epub 2012 Apr 13. J Immunol. 2012. PMID: 22504645 Free PMC article.
Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.
Lindestam Arlehamn CS, Gerasimova A, Mele F, Henderson R, Swann J, Greenbaum JA, Kim Y, Sidney J, James EA, Taplitz R, McKinney DM, Kwok WW, Grey H, Sallusto F, Peters B, Sette A. Lindestam Arlehamn CS, et al. Among authors: mckinney dm. PLoS Pathog. 2013 Jan;9(1):e1003130. doi: 10.1371/journal.ppat.1003130. Epub 2013 Jan 24. PLoS Pathog. 2013. PMID: 23358848 Free PMC article.
A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population.
McKinney DM, Southwood S, Hinz D, Oseroff C, Arlehamn CS, Schulten V, Taplitz R, Broide D, Hanekom WA, Scriba TJ, Wood R, Alam R, Peters B, Sidney J, Sette A. McKinney DM, et al. Immunogenetics. 2013 May;65(5):357-70. doi: 10.1007/s00251-013-0684-y. Epub 2013 Feb 8. Immunogenetics. 2013. PMID: 23392739 Free PMC article.
36 results