Wierdl M - Search Results

1

Carboxylesterases: General detoxifying enzymes.

Hatfield MJ, Umans RA, Hyatt JL, Edwards CC, Wierdl M, Tsurkan L, Taylor MR, Potter PM. Hatfield MJ, et al. Among authors: wierdl m. Chem Biol Interact. 2016 Nov 25;259(Pt B):327-331. doi: 10.1016/j.cbi.2016.02.011. Epub 2016 Feb 15. Chem Biol Interact. 2016. PMID: 26892220 Free PMC article. Review.

2

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM. Hyatt JL, et al. Among authors: wierdl m. J Med Chem. 2005 Aug 25;48(17):5543-50. doi: 10.1021/jm0504196. J Med Chem. 2005. PMID: 16107154

3

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt JL, Tsurkan L, Wierdl M, Edwards CC, Danks MK, Potter PM. Hyatt JL, et al. Among authors: wierdl m. Mol Cancer Ther. 2006 Sep;5(9):2281-8. doi: 10.1158/1535-7163.MCT-06-0160. Mol Cancer Ther. 2006. PMID: 16985062

4

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: wierdl m. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546

5

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: wierdl m. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. doi: 10.1016/j.bmc.2007.03.012. Epub 2007 Mar 12. Bioorg Med Chem. 2007. PMID: 17399985 Free PMC article.

6

Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer.

Wierdl M, Tsurkan L, Hatfield MJ, Potter PM. Wierdl M, et al. Br J Pharmacol. 2016 Oct;173(19):2811-8. doi: 10.1111/bph.13553. Epub 2016 Aug 22. Br J Pharmacol. 2016. PMID: 27423046 Free PMC article. Review.

7

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.

Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM. Wierdl M, et al. Biochemistry. 2004 Feb 24;43(7):1874-82. doi: 10.1021/bi035586r. Biochemistry. 2004. PMID: 14967028

8

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. Among authors: wierdl m. J Med Chem. 2005 Apr 21;48(8):2906-15. doi: 10.1021/jm049011j. J Med Chem. 2005. PMID: 15828829

9

Modifications of human carboxylesterase for improved prodrug activation.

Hatfield JM, Wierdl M, Wadkins RM, Potter PM. Hatfield JM, et al. Among authors: wierdl m. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1153-65. doi: 10.1517/17425255.4.9.1153. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721110 Free PMC article. Review.

10

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR. Hemmert AC, et al. Among authors: wierdl m. PLoS One. 2011 Mar 18;6(3):e17441. doi: 10.1371/journal.pone.0017441. PLoS One. 2011. PMID: 21445272 Free PMC article.

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