Fernandes HJ - Search Results

1

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.

Fernandes HJ, Hartfield EM, Christian HC, Emmanoulidou E, Zheng Y, Booth H, Bogetofte H, Lang C, Ryan BJ, Sardi SP, Badger J, Vowles J, Evetts S, Tofaris GK, Vekrellis K, Talbot K, Hu MT, James W, Cowley SA, Wade-Martins R. Fernandes HJ, et al. Stem Cell Reports. 2016 Mar 8;6(3):342-56. doi: 10.1016/j.stemcr.2016.01.013. Epub 2016 Feb 18. Stem Cell Reports. 2016. PMID: 26905200 Free PMC article.

2

Cellular reprogramming: a new approach to modelling Parkinson's disease.

Hartfield EM, Fernandes HJ, Vowles J, Cowley SA, Wade-Martins R. Hartfield EM, et al. Among authors: fernandes hj. Biochem Soc Trans. 2012 Oct;40(5):1152-7. doi: 10.1042/BST20120159. Biochem Soc Trans. 2012. PMID: 22988881 Review.

3

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.

Vazquez-Arango P, Vowles J, Browne C, Hartfield E, Fernandes HJ, Mandefro B, Sareen D, James W, Wade-Martins R, Cowley SA, Murphy S, O'Reilly D. Vazquez-Arango P, et al. Among authors: fernandes hj. Nucleic Acids Res. 2016 Dec 15;44(22):10960-10973. doi: 10.1093/nar/gkw711. Epub 2016 Aug 17. Nucleic Acids Res. 2016. PMID: 27536002 Free PMC article.

4

Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.

Fernandes HJ, Ryan BJ, Wade-Martins R. Fernandes HJ, et al. Front Neurosci. 2016 Dec 23;10:578. doi: 10.3389/fnins.2016.00578. eCollection 2016. Front Neurosci. 2016. PMID: 28066164 Free PMC article. No abstract available.

5

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon F, Cherubini M, Fernandes HJR, Lang C, Ryan BJ, Volpato V, Bengoa-Vergniory N, Vingill S, Attar M, Booth HDE, Haenseler W, Vowles J, Bowden R, Webber C, Cowley SA, Wade-Martins R. Zambon F, et al. Hum Mol Genet. 2019 Jun 15;28(12):2001-2013. doi: 10.1093/hmg/ddz038. Hum Mol Genet. 2019. PMID: 30753527 Free PMC article.

6

Single-Cell Transcriptomics of Parkinson's Disease Human In Vitro Models Reveals Dopamine Neuron-Specific Stress Responses.

Fernandes HJR, Patikas N, Foskolou S, Field SF, Park JE, Byrne ML, Bassett AR, Metzakopian E. Fernandes HJR, et al. Cell Rep. 2020 Oct 13;33(2):108263. doi: 10.1016/j.celrep.2020.108263. Cell Rep. 2020. PMID: 33053338 Free article.

7

Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons.

Bogetofte H, Ryan BJ, Jensen P, Schmidt SI, Vergoossen DLE, Barnkob MB, Kiani LN, Chughtai U, Heon-Roberts R, Caiazza MC, McGuinness W, Márquez-Gómez R, Vowles J, Bunn FS, Brandes J, Kilfeather P, Connor JP, Fernandes HJR, Caffrey TM, Meyer M, Cowley SA, Larsen MR, Wade-Martins R. Bogetofte H, et al. Among authors: fernandes hjr. Cell Rep. 2023 Mar 28;42(3):112180. doi: 10.1016/j.celrep.2023.112180. Epub 2023 Mar 3. Cell Rep. 2023. PMID: 36870058 Free article.

8

CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death.

Pavlou S, Foskolou S, Patikas N, Field SF, Papachristou EK, Santos C, Edwards AR, Kishore K, Ansari R, Rajan SS, Fernandes HJR, Metzakopian E. Pavlou S, et al. Among authors: fernandes hjr. Sci Rep. 2023 Mar 9;13(1):3934. doi: 10.1038/s41598-023-31141-6. Sci Rep. 2023. PMID: 36894612 Free PMC article.

9

Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.

Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, Bassett A, Karran E, Miller BL, Fleming A, Rubinsztein DC. Siddiqi FH, et al. Nat Commun. 2019 Apr 18;10(1):1817. doi: 10.1038/s41467-019-09494-2. Nat Commun. 2019. PMID: 31000720 Free PMC article.

10

Changes in Oxidised Phospholipids in Response to Oxidative Stress in Microtubule-Associated Protein Tau (MAPT) Mutant Dopamine Neurons.

Bradford X, Fernandes HJR, Snowden SG. Bradford X, et al. Among authors: fernandes hjr. Antioxidants (Basel). 2024 Apr 24;13(5):508. doi: 10.3390/antiox13050508. Antioxidants (Basel). 2024. PMID: 38790613 Free PMC article.

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