Luminal cysteine-proteases degrade colonic tight junction structure and are responsible for abdominal pain in constipation-predominant IBS.
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Am J Gastroenterol. 2013 Aug;108(8):1322-31. doi: 10.1038/ajg.2013.152. Epub 2013 May 28.
Am J Gastroenterol. 2013.
PMID: 23711626