Orlicky S - Search Results

1

Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.

Gorelik M, Orlicky S, Sartori MA, Tang X, Marcon E, Kurinov I, Greenblatt JF, Tyers M, Moffat J, Sicheri F, Sidhu SS. Gorelik M, et al. Among authors: orlicky s. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3527-32. doi: 10.1073/pnas.1519389113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976582 Free PMC article.

2

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.

Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M. Nash P, et al. Among authors: orlicky s. Nature. 2001 Nov 29;414(6863):514-21. doi: 10.1038/35107009. Nature. 2001. PMID: 11734846

3

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase.

Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Orlicky S, et al. Cell. 2003 Jan 24;112(2):243-56. doi: 10.1016/s0092-8674(03)00034-5. Cell. 2003. PMID: 12553912 Free article.

4

Genome-wide surveys for phosphorylation-dependent substrates of SCF ubiquitin ligases.

Tang X, Orlicky S, Liu Q, Willems A, Sicheri F, Tyers M. Tang X, et al. Among authors: orlicky s. Methods Enzymol. 2005;399:433-58. doi: 10.1016/S0076-6879(05)99030-7. Methods Enzymol. 2005. PMID: 16338374

5

Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination.

Tang X, Orlicky S, Lin Z, Willems A, Neculai D, Ceccarelli D, Mercurio F, Shilton BH, Sicheri F, Tyers M. Tang X, et al. Among authors: orlicky s. Cell. 2007 Jun 15;129(6):1165-76. doi: 10.1016/j.cell.2007.04.042. Cell. 2007. PMID: 17574027 Free article.

6

Interactome and interface protocol (2IP): a novel strategy for high sensitivity topology mapping of protein complexes.

Weerasekera R, She YM, Markham KA, Bai Y, Opalka N, Orlicky S, Sicheri F, Kislinger T, Schmitt-Ulms G. Weerasekera R, et al. Among authors: orlicky s. Proteomics. 2007 Nov;7(21):3835-52. doi: 10.1002/pmic.200700688. Proteomics. 2007. PMID: 17960736

7

Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.

Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, Durocher D, Sicheri F. Mao DY, et al. Among authors: orlicky s. Mol Cell. 2008 Oct 24;32(2):259-75. doi: 10.1016/j.molcel.2008.10.002. Mol Cell. 2008. PMID: 18951093 Free PMC article.

8

Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor.

Mittag T, Orlicky S, Choy WY, Tang X, Lin H, Sicheri F, Kay LE, Tyers M, Forman-Kay JD. Mittag T, et al. Among authors: orlicky s. Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17772-7. doi: 10.1073/pnas.0809222105. Epub 2008 Nov 13. Proc Natl Acad Sci U S A. 2008. PMID: 19008353 Free PMC article.

9

Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase.

Mittag T, Marsh J, Grishaev A, Orlicky S, Lin H, Sicheri F, Tyers M, Forman-Kay JD. Mittag T, et al. Among authors: orlicky s. Structure. 2010 Mar 14;18(4):494-506. doi: 10.1016/j.str.2010.01.020. Structure. 2010. PMID: 20399186 Free PMC article.

10

An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase.

Orlicky S, Tang X, Neduva V, Elowe N, Brown ED, Sicheri F, Tyers M. Orlicky S, et al. Nat Biotechnol. 2010 Jul;28(7):733-7. doi: 10.1038/nbt.1646. Epub 2010 Jun 27. Nat Biotechnol. 2010. PMID: 20581844 Free PMC article.

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