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Page 1
Discovery of a potent and selective GPR120 agonist.
Shimpukade B, Hudson BD, Hovgaard CK, Milligan G, Ulven T. Shimpukade B, et al. J Med Chem. 2012 May 10;55(9):4511-5. doi: 10.1021/jm300215x. Epub 2012 May 2. J Med Chem. 2012. PMID: 22519963
The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism.
Hudson BD, Shimpukade B, Mackenzie AE, Butcher AJ, Pediani JD, Christiansen E, Heathcote H, Tobin AB, Ulven T, Milligan G. Hudson BD, et al. Among authors: shimpukade b. Mol Pharmacol. 2013 Nov;84(5):710-25. doi: 10.1124/mol.113.087783. Epub 2013 Aug 26. Mol Pharmacol. 2013. PMID: 23979972 Free PMC article.
Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area, and Robust in Vivo Efficacy.
Hansen SV, Christiansen E, Urban C, Hudson BD, Stocker CJ, Due-Hansen ME, Wargent ET, Shimpukade B, Almeida R, Ejsing CS, Cawthorne MA, Kassack MU, Milligan G, Ulven T. Hansen SV, et al. Among authors: shimpukade b. J Med Chem. 2016 Mar 24;59(6):2841-6. doi: 10.1021/acs.jmedchem.5b01962. Epub 2016 Mar 15. J Med Chem. 2016. PMID: 26928019
Complex Pharmacology of Free Fatty Acid Receptors.
Milligan G, Shimpukade B, Ulven T, Hudson BD. Milligan G, et al. Among authors: shimpukade b. Chem Rev. 2017 Jan 11;117(1):67-110. doi: 10.1021/acs.chemrev.6b00056. Epub 2016 Jun 14. Chem Rev. 2017. PMID: 27299848 Free article. Review.
Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity.
Azevedo CM, Watterson KR, Wargent ET, Hansen SV, Hudson BD, Kępczyńska MA, Dunlop J, Shimpukade B, Christiansen E, Milligan G, Stocker CJ, Ulven T. Azevedo CM, et al. Among authors: shimpukade b. J Med Chem. 2016 Oct 13;59(19):8868-8878. doi: 10.1021/acs.jmedchem.6b00685. Epub 2016 Sep 22. J Med Chem. 2016. PMID: 27570890
The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.
Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, Dib LH, Mol IM, Caengprasath N, Chan YW, Damak S, Miller AR, Coskun T, Shimpukade B, Ulven T, Kooijman S, Rensen PC, Christian M. Schilperoort M, et al. Among authors: shimpukade b. EMBO Mol Med. 2018 Mar;10(3):e8047. doi: 10.15252/emmm.201708047. EMBO Mol Med. 2018. PMID: 29343498 Free PMC article.
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