Wang Y - Search Results

1

Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice.

Shemesh CS, Yu RZ, Gaus HJ, Seth PP, Swayze EE, Bennett FC, Geary RS, Henry SP, Wang Y. Shemesh CS, et al. Among authors: wang y. Nucleic Acid Ther. 2016 Aug;26(4):223-35. doi: 10.1089/nat.2016.0607. Epub 2016 Mar 31. Nucleic Acid Ther. 2016. PMID: 27031383

2

Lack of QT Prolongation for 2'-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlled Studies in Healthy Subjects.

Yu RZ, Gunawan R, Geary RS, Hughes SG, Henry SP, Wang Y. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2017 Oct;27(5):285-294. doi: 10.1089/nat.2017.0676. Epub 2017 Aug 11. Nucleic Acid Ther. 2017. PMID: 28799823 Free PMC article. Clinical Trial.

3

Integrated Assessment of the Clinical Performance of GalNAc₃-Conjugated 2'-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience.

Crooke ST, Baker BF, Xia S, Yu RZ, Viney NJ, Wang Y, Tsimikas S, Geary RS. Crooke ST, et al. Among authors: wang y. Nucleic Acid Ther. 2019 Feb;29(1):16-32. doi: 10.1089/nat.2018.0753. Epub 2018 Dec 20. Nucleic Acid Ther. 2019. PMID: 30570431 Free PMC article. Clinical Trial.

4

Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc₃-Conjugated Antisense Oligonucleotides.

Wang Y, Yu RZ, Henry S, Geary RS. Wang Y, et al. Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):475-485. doi: 10.1080/17425255.2019.1621838. Epub 2019 May 30. Expert Opin Drug Metab Toxicol. 2019. PMID: 31144994 Review.

5

Population Pharmacokinetic-Pharmacodynamic Modeling of Inotersen, an Antisense Oligonucleotide for Treatment of Patients with Hereditary Transthyretin Amyloidosis.

Yu RZ, Collins JW, Hall S, Ackermann EJ, Geary RS, Monia BP, Henry SP, Wang Y. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2020 Jun;30(3):153-163. doi: 10.1089/nat.2019.0822. Epub 2020 Apr 15. Nucleic Acid Ther. 2020. PMID: 32286934 Free PMC article. Clinical Trial.

6

Immunogenicity Assessment of Inotersen, a 2'-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety.

Yu RZ, Wang Y, Norris DA, Kim TW, Narayanan P, Geary RS, Monia BP, Henry SP. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2020 Oct;30(5):265-275. doi: 10.1089/nat.2020.0867. Epub 2020 Aug 19. Nucleic Acid Ther. 2020. PMID: 32833564 Clinical Trial.

7

Interspecies Scaling of Human Clearance and Plasma Trough Exposure for Antisense Oligonucleotides: A Retrospective Analysis of GalNAc3-Conjugated and Unconjugated-Antisense Oligonucleotides.

Nanavati C, McMullen G, Yu R, Geary RS, Henry SP, Wang Y. Nanavati C, et al. Among authors: wang y. Nucleic Acid Ther. 2021 Aug;31(4):298-308. doi: 10.1089/nat.2020.0911. Epub 2021 Apr 23. Nucleic Acid Ther. 2021. PMID: 33891483

8

Lack of Interactions Between an Antisense Oligonucleotide with 2'-O-(2-Methoxyethyl) Modifications and Major Drug Transporters.

Yu RZ, Warren MS, Watanabe T, Nichols B, Jahic M, Huang J, Burkey J, Geary RS, Henry SP, Wang Y. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2016 Apr;26(2):111-7. doi: 10.1089/nat.2015.0588. Epub 2016 Mar 9. Nucleic Acid Ther. 2016. PMID: 26959999

9

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys.

Shemesh CS, Yu RZ, Gaus HJ, Greenlee S, Post N, Schmidt K, Migawa MT, Seth PP, Zanardi TA, Prakash TP, Swayze EE, Henry SP, Wang Y. Shemesh CS, et al. Among authors: wang y. Mol Ther Nucleic Acids. 2016 May 10;5(5):e319. doi: 10.1038/mtna.2016.31. Mol Ther Nucleic Acids. 2016. PMID: 27164023 Free PMC article.

10

Disposition and Pharmacokinetics of a GalNAc3-Conjugated Antisense Oligonucleotide Targeting Human Lipoprotein (a) in Monkeys.

Yu RZ, Gunawan R, Post N, Zanardi T, Hall S, Burkey J, Kim TW, Graham MJ, Prakash TP, Seth PP, Swayze EE, Geary RS, Henry SP, Wang Y. Yu RZ, et al. Among authors: wang y. Nucleic Acid Ther. 2016 Dec;26(6):372-380. doi: 10.1089/nat.2016.0623. Epub 2016 Aug 8. Nucleic Acid Ther. 2016. PMID: 27500733

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