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Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth.
Chukwuma VU, Kose N, Sather DN, Sapparapu G, Falk R, King H, Singh V, Lampley R, Malherbe DC, Ditto NT, Sullivan JT, Barnes T, Doranz BJ, Labranche CC, Montefiori DC, Kalams SA, Haigwood NL, Crowe JE Jr. Chukwuma VU, et al. Among authors: sapparapu g. PLoS One. 2018 Dec 19;13(12):e0209437. doi: 10.1371/journal.pone.0209437. eCollection 2018. PLoS One. 2018. PMID: 30566528 Free PMC article.
Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth.
Willis JR, Sapparapu G, Murrell S, Julien JP, Singh V, King HG, Xia Y, Pickens JA, LaBranche CC, Slaughter JC, Montefiori DC, Wilson IA, Meiler J, Crowe JE Jr. Willis JR, et al. Among authors: sapparapu g. J Clin Invest. 2015 Jun;125(6):2523-31. doi: 10.1172/JCI80693. Epub 2015 May 18. J Clin Invest. 2015. PMID: 25985274 Free PMC article.
Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity.
Long F, Fong RH, Austin SK, Chen Z, Klose T, Fokine A, Liu Y, Porta J, Sapparapu G, Akahata W, Doranz BJ, Crowe JE Jr, Diamond MS, Rossmann MG. Long F, et al. Among authors: sapparapu g. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13898-903. doi: 10.1073/pnas.1515558112. Epub 2015 Oct 26. Proc Natl Acad Sci U S A. 2015. PMID: 26504196 Free PMC article.
Recognition of influenza H3N2 variant virus by human neutralizing antibodies.
Bangaru S, Nieusma T, Kose N, Thornburg NJ, Finn JA, Kaplan BS, King HG, Singh V, Lampley RM, Sapparapu G, Cisneros A 3rd, Edwards KM, Slaughter JC, Edupuganti S, Lai L, Richt JA, Webby RJ, Ward AB, Crowe JE Jr. Bangaru S, et al. Among authors: sapparapu g. JCI Insight. 2016 Jul 7;1(10):e86673. doi: 10.1172/jci.insight.86673. JCI Insight. 2016. PMID: 27482543 Free PMC article.
Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody.
Shanker S, Czakó R, Sapparapu G, Alvarado G, Viskovska M, Sankaran B, Atmar RL, Crowe JE Jr, Estes MK, Prasad BV. Shanker S, et al. Among authors: sapparapu g. Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5830-E5837. doi: 10.1073/pnas.1609990113. Epub 2016 Sep 19. Proc Natl Acad Sci U S A. 2016. PMID: 27647885 Free PMC article.
Human rotavirus VP6-specific antibodies mediate intracellular neutralization by binding to a quaternary structure in the transcriptional pore.
Aiyegbo MS, Sapparapu G, Spiller BW, Eli IM, Williams DR, Kim R, Lee DE, Liu T, Li S, Woods VL Jr, Nannemann DP, Meiler J, Stewart PL, Crowe JE Jr. Aiyegbo MS, et al. Among authors: sapparapu g. PLoS One. 2013 May 9;8(5):e61101. doi: 10.1371/journal.pone.0061101. Print 2013. PLoS One. 2013. PMID: 23671563 Free PMC article.
Mechanism of human antibody-mediated neutralization of Marburg virus.
Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, Crowe JE Jr. Flyak AI, et al. Among authors: sapparapu g. Cell. 2015 Feb 26;160(5):893-903. doi: 10.1016/j.cell.2015.01.031. Cell. 2015. PMID: 25723164 Free PMC article.
Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection.
Flyak AI, Shen X, Murin CD, Turner HL, David JA, Fusco ML, Lampley R, Kose N, Ilinykh PA, Kuzmina N, Branchizio A, King H, Brown L, Bryan C, Davidson E, Doranz BJ, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Saphire EO, Ward AB, Bukreyev A, Crowe JE Jr. Flyak AI, et al. Among authors: sapparapu g. Cell. 2016 Jan 28;164(3):392-405. doi: 10.1016/j.cell.2015.12.022. Epub 2016 Jan 21. Cell. 2016. PMID: 26806128 Free PMC article.
33 results