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Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA.
Fehrmann RS, Jansen RC, Veldink JH, Westra HJ, Arends D, Bonder MJ, Fu J, Deelen P, Groen HJ, Smolonska A, Weersma RK, Hofstra RM, Buurman WA, Rensen S, Wolfs MG, Platteel M, Zhernakova A, Elbers CC, Festen EM, Trynka G, Hofker MH, Saris CG, Ophoff RA, van den Berg LH, van Heel DA, Wijmenga C, Te Meerman GJ, Franke L. Fehrmann RS, et al. Among authors: fu j. PLoS Genet. 2011 Aug;7(8):e1002197. doi: 10.1371/journal.pgen.1002197. Epub 2011 Aug 4. PLoS Genet. 2011. PMID: 21829388 Free PMC article.
Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression.
Fu J, Wolfs MG, Deelen P, Westra HJ, Fehrmann RS, Te Meerman GJ, Buurman WA, Rensen SS, Groen HJ, Weersma RK, van den Berg LH, Veldink J, Ophoff RA, Snieder H, van Heel D, Jansen RC, Hofker MH, Wijmenga C, Franke L. Fu J, et al. PLoS Genet. 2012 Jan;8(1):e1002431. doi: 10.1371/journal.pgen.1002431. Epub 2012 Jan 19. PLoS Genet. 2012. PMID: 22275870 Free PMC article.
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression.
Kumar V, Westra HJ, Karjalainen J, Zhernakova DV, Esko T, Hrdlickova B, Almeida R, Zhernakova A, Reinmaa E, Võsa U, Hofker MH, Fehrmann RS, Fu J, Withoff S, Metspalu A, Franke L, Wijmenga C. Kumar V, et al. Among authors: fu j. PLoS Genet. 2013;9(1):e1003201. doi: 10.1371/journal.pgen.1003201. Epub 2013 Jan 17. PLoS Genet. 2013. PMID: 23341781 Free PMC article.
Pleiotropic effects of lipid genes on plasma glucose, HbA1c, and HOMA-IR levels.
Li N, van der Sijde MR; LifeLines Cohort Study Group; Bakker SJ, Dullaart RP, van der Harst P, Gansevoort RT, Elbers CC, Wijmenga C, Snieder H, Hofker MH, Fu J. Li N, et al. Among authors: fu j. Diabetes. 2014 Sep;63(9):3149-58. doi: 10.2337/db13-1800. Epub 2014 Apr 10. Diabetes. 2014. PMID: 24722249
Genetic and epigenetic regulation of gene expression in fetal and adult human livers.
Bonder MJ, Kasela S, Kals M, Tamm R, Lokk K, Barragan I, Buurman WA, Deelen P, Greve JW, Ivanov M, Rensen SS, van Vliet-Ostaptchouk JV, Wolfs MG, Fu J, Hofker MH, Wijmenga C, Zhernakova A, Ingelman-Sundberg M, Franke L, Milani L. Bonder MJ, et al. Among authors: fu j. BMC Genomics. 2014 Oct 4;15(1):860. doi: 10.1186/1471-2164-15-860. BMC Genomics. 2014. PMID: 25282492 Free PMC article.
Apple or pear: size and shape matter.
Fu J, Hofker M, Wijmenga C. Fu J, et al. Cell Metab. 2015 Apr 7;21(4):507-8. doi: 10.1016/j.cmet.2015.03.016. Cell Metab. 2015. PMID: 25863240 Free article.
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