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853 results

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Page 1
Discovery of G Protein-Biased EP2 Receptor Agonists.
Ogawa S, Watanabe T, Sugimoto I, Moriyuki K, Goto Y, Yamane S, Watanabe A, Tsuboi K, Kinoshita A, Kigoshi H, Tani K, Maruyama T. Ogawa S, et al. Among authors: kinoshita a. ACS Med Chem Lett. 2016 Jan 4;7(3):306-11. doi: 10.1021/acsmedchemlett.5b00455. eCollection 2016 Mar 10. ACS Med Chem Lett. 2016. PMID: 26985320 Free PMC article.
Discovery of new orally active prostaglandin D2 receptor antagonists.
Iwahashi M, Naganawa A, Kinoshita A, Shimabukuro A, Nishiyama T, Ogawa S, Matsunaga Y, Tsukamoto K, Okada Y, Matsumoto R, Nambu F, Oumi R, Odagaki Y, Katagi J, Yano K, Tani K, Nakai H, Toda M. Iwahashi M, et al. Among authors: kinoshita a. Bioorg Med Chem. 2011 Nov 15;19(22):6935-48. doi: 10.1016/j.bmc.2011.08.065. Epub 2011 Sep 2. Bioorg Med Chem. 2011. PMID: 21982795
3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.
Asada M, Iwahashi M, Obitsu T, Kinoshita A, Nakai Y, Onoda T, Nagase T, Tanaka M, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: kinoshita a. Bioorg Med Chem. 2010 Feb 15;18(4):1641-58. doi: 10.1016/j.bmc.2009.12.068. Epub 2010 Jan 4. Bioorg Med Chem. 2010. PMID: 20129791
3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs.
Asada M, Obitsu T, Kinoshita A, Nagase T, Yoshida T, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Nakai H, Toda M, Tobe Y. Asada M, et al. Among authors: kinoshita a. Bioorg Med Chem. 2010 May 1;18(9):3212-23. doi: 10.1016/j.bmc.2010.03.028. Epub 2010 Mar 17. Bioorg Med Chem. 2010. PMID: 20385498
Discovery of Gemilukast (ONO-6950), a Dual CysLT1 and CysLT2 Antagonist As a Therapeutic Agent for Asthma.
Itadani S, Yashiro K, Aratani Y, Sekiguchi T, Kinoshita A, Moriguchi H, Ohta N, Takahashi S, Ishida A, Tajima Y, Hisaichi K, Ima M, Ueda J, Egashira H, Sekioka T, Kadode M, Yonetomi Y, Nakao T, Inoue A, Nomura H, Kitamine T, Fujita M, Nabe T, Yamaura Y, Matsumura N, Imagawa A, Nakayama Y, Takeuchi J, Ohmoto K. Itadani S, et al. Among authors: kinoshita a. J Med Chem. 2015 Aug 13;58(15):6093-113. doi: 10.1021/acs.jmedchem.5b00741. Epub 2015 Jul 22. J Med Chem. 2015. PMID: 26200813
853 results