Kumar AP - Search Results

1

Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma.

Huang B, Deng S, Loo SY, Datta A, Yap YL, Yan B, Ooi CH, Dinh TD, Zhuo J, Tochhawng L, Gopinadhan S, Jegadeesan T, Tan P, Salto-Tellez M, Yong WP, Soong R, Yeoh KG, Goh YC, Lobie PE, Yang H, Kumar AP, Maciver SK, So JB, Yap CT. Huang B, et al. Among authors: kumar ap. Oncotarget. 2016 May 3;7(18):25391-407. doi: 10.18632/oncotarget.8603. Oncotarget. 2016. PMID: 27058427 Free PMC article.

2

Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo.

Kumar AP, Quake AL, Chang MK, Zhou T, Lim KS, Singh R, Hewitt RE, Salto-Tellez M, Pervaiz S, Clément MV. Kumar AP, et al. Cancer Res. 2009 Nov 15;69(22):8636-44. doi: 10.1158/0008-5472.CAN-09-0219. Epub 2009 Nov 3. Cancer Res. 2009. PMID: 19887620

3

γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.

Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G. Rajendran P, et al. Among authors: kumar ap. Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x. Br J Pharmacol. 2011. PMID: 21198544 Free PMC article.

4

Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway.

Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH. Woo CC, et al. Among authors: kumar ap. Biochem Pharmacol. 2011 Sep 1;82(5):464-75. doi: 10.1016/j.bcp.2011.05.030. Epub 2011 Jun 14. Biochem Pharmacol. 2011. PMID: 21679698

5

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways.

Kannaiyan R, Manu KA, Chen L, Li F, Rajendran P, Subramaniam A, Lam P, Kumar AP, Sethi G. Kannaiyan R, et al. Among authors: kumar ap. Apoptosis. 2011 Oct;16(10):1028-41. doi: 10.1007/s10495-011-0629-6. Apoptosis. 2011. PMID: 21786165

6

First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.

Manu KA, Shanmugam MK, Ramachandran L, Li F, Fong CW, Kumar AP, Tan P, Sethi G. Manu KA, et al. Among authors: kumar ap. Clin Cancer Res. 2012 Apr 15;18(8):2220-9. doi: 10.1158/1078-0432.CCR-11-2470. Epub 2012 Feb 20. Clin Cancer Res. 2012. PMID: 22351692 Free article.

7

NHE-1: a promising target for novel anti-cancer therapeutics.

Loo SY, Chang MK, Chua CS, Kumar AP, Pervaiz S, Clement MV. Loo SY, et al. Among authors: kumar ap. Curr Pharm Des. 2012;18(10):1372-82. doi: 10.2174/138161212799504885. Curr Pharm Des. 2012. PMID: 22360552 Review.

8

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade.

Zhuo J, Tan EH, Yan B, Tochhawng L, Jayapal M, Koh S, Tay HK, Maciver SK, Hooi SC, Salto-Tellez M, Kumar AP, Goh YC, Lim YC, Yap CT. Zhuo J, et al. Among authors: kumar ap. PLoS One. 2012;7(8):e43594. doi: 10.1371/journal.pone.0043594. Epub 2012 Aug 21. PLoS One. 2012. PMID: 22927998 Free PMC article.

9

Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.

Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G. Ramachandran L, et al. Among authors: kumar ap. J Biol Chem. 2012 Nov 2;287(45):38028-40. doi: 10.1074/jbc.M112.388702. Epub 2012 Sep 19. J Biol Chem. 2012. PMID: 22992727 Free PMC article.

10

An anthraquinone derivative, emodin sensitizes hepatocellular carcinoma cells to TRAIL induced apoptosis through the induction of death receptors and downregulation of cell survival proteins.

Subramaniam A, Loo SY, Rajendran P, Manu KA, Perumal E, Li F, Shanmugam MK, Siveen KS, Park JI, Ahn KS, Hui KM, Kumar AP, Sethi G. Subramaniam A, et al. Among authors: kumar ap. Apoptosis. 2013 Oct;18(10):1175-87. doi: 10.1007/s10495-013-0851-5. Apoptosis. 2013. PMID: 23700228

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