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HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.
Stegen S, van Gastel N, Eelen G, Ghesquière B, D'Anna F, Thienpont B, Goveia J, Torrekens S, Van Looveren R, Luyten FP, Maxwell PH, Wielockx B, Lambrechts D, Fendt SM, Carmeliet P, Carmeliet G. Stegen S, et al. Among authors: torrekens s. Cell Metab. 2016 Feb 9;23(2):265-79. doi: 10.1016/j.cmet.2016.01.002. Cell Metab. 2016. PMID: 26863487 Free PMC article.
HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.
Stegen S, Laperre K, Eelen G, Rinaldi G, Fraisl P, Torrekens S, Van Looveren R, Loopmans S, Bultynck G, Vinckier S, Meersman F, Maxwell PH, Rai J, Weis M, Eyre DR, Ghesquière B, Fendt SM, Carmeliet P, Carmeliet G. Stegen S, et al. Among authors: torrekens s. Nature. 2019 Jan;565(7740):511-515. doi: 10.1038/s41586-019-0874-3. Epub 2019 Jan 16. Nature. 2019. PMID: 30651640 Free PMC article.
Lipid availability determines fate of skeletal progenitor cells via SOX9.
van Gastel N, Stegen S, Eelen G, Schoors S, Carlier A, Daniëls VW, Baryawno N, Przybylski D, Depypere M, Stiers PJ, Lambrechts D, Van Looveren R, Torrekens S, Sharda A, Agostinis P, Lambrechts D, Maes F, Swinnen JV, Geris L, Van Oosterwyck H, Thienpont B, Carmeliet P, Scadden DT, Carmeliet G. van Gastel N, et al. Among authors: torrekens s. Nature. 2020 Mar;579(7797):111-117. doi: 10.1038/s41586-020-2050-1. Epub 2020 Feb 26. Nature. 2020. PMID: 32103177 Free PMC article.
Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle.
Tournaire G, Loopmans S, Stegen S, Rinaldi G, Eelen G, Torrekens S, Moermans K, Carmeliet P, Ghesquière B, Thienpont B, Fendt SM, van Gastel N, Carmeliet G. Tournaire G, et al. Among authors: torrekens s. Cell Rep. 2022 Jul 26;40(4):111105. doi: 10.1016/j.celrep.2022.111105. Cell Rep. 2022. PMID: 35905715 Free PMC article.
43 results