Granzier HL - Search Results

1

Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats.

Kovács Á, Fülöp GÁ, Kovács A, Csípő T, Bódi B, Priksz D, Juhász B, Beke L, Hendrik Z, Méhes G, Granzier HL, Édes I, Fagyas M, Papp Z, Barta J, Tóth A. Kovács Á, et al. Among authors: granzier hl. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1671-82. doi: 10.1152/ajpheart.00842.2015. Epub 2016 Apr 8. Am J Physiol Heart Circ Physiol. 2016. PMID: 27059079 Free article.

2

Excision of titin's cardiac PEVK spring element abolishes PKCalpha-induced increases in myocardial stiffness.

Hudson BD, Hidalgo CG, Gotthardt M, Granzier HL. Hudson BD, et al. Among authors: granzier hl. J Mol Cell Cardiol. 2010 May;48(5):972-8. doi: 10.1016/j.yjmcc.2009.12.006. Epub 2009 Dec 21. J Mol Cell Cardiol. 2010. PMID: 20026128 Free PMC article.

3

Calcium sensitivity and the Frank-Starling mechanism of the heart are increased in titin N2B region-deficient mice.

Lee EJ, Peng J, Radke M, Gotthardt M, Granzier HL. Lee EJ, et al. Among authors: granzier hl. J Mol Cell Cardiol. 2010 Sep;49(3):449-58. doi: 10.1016/j.yjmcc.2010.05.006. Epub 2010 May 23. J Mol Cell Cardiol. 2010. PMID: 20507834 Free PMC article.

4

Hyperphosphorylation of mouse cardiac titin contributes to transverse aortic constriction-induced diastolic dysfunction.

Hudson B, Hidalgo C, Saripalli C, Granzier H. Hudson B, et al. Circ Res. 2011 Sep 30;109(8):858-66. doi: 10.1161/CIRCRESAHA.111.246819. Epub 2011 Aug 11. Circ Res. 2011. PMID: 21835910 Free PMC article.

5

Titin-based tension in the cardiac sarcomere: molecular origin and physiological adaptations.

Anderson BR, Granzier HL. Anderson BR, et al. Among authors: granzier hl. Prog Biophys Mol Biol. 2012 Oct-Nov;110(2-3):204-17. doi: 10.1016/j.pbiomolbio.2012.08.003. Epub 2012 Aug 11. Prog Biophys Mol Biol. 2012. PMID: 22910434 Free PMC article. Review.

6

Tuning the molecular giant titin through phosphorylation: role in health and disease.

Hidalgo C, Granzier H. Hidalgo C, et al. Trends Cardiovasc Med. 2013 Jul;23(5):165-71. doi: 10.1016/j.tcm.2012.10.005. Epub 2013 Jan 5. Trends Cardiovasc Med. 2013. PMID: 23295080 Free PMC article. Review.

7

Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction.

Chung CS, Hutchinson KR, Methawasin M, Saripalli C, Smith JE 3rd, Hidalgo CG, Luo X, Labeit S, Guo C, Granzier HL. Chung CS, et al. Among authors: granzier hl. Circulation. 2013 Jul 2;128(1):19-28. doi: 10.1161/CIRCULATIONAHA.112.001268. Epub 2013 May 24. Circulation. 2013. PMID: 23709671 Free PMC article.

8

Cardiac titin and heart disease.

LeWinter MM, Granzier HL. LeWinter MM, et al. Among authors: granzier hl. J Cardiovasc Pharmacol. 2014 Mar;63(3):207-12. doi: 10.1097/FJC.0000000000000007. J Cardiovasc Pharmacol. 2014. PMID: 24072177 Free PMC article. Review.

9

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy.

Buck D, Smith JE 3rd, Chung CS, Ono Y, Sorimachi H, Labeit S, Granzier HL. Buck D, et al. Among authors: granzier hl. J Gen Physiol. 2014 Feb;143(2):215-30. doi: 10.1085/jgp.201311129. J Gen Physiol. 2014. PMID: 24470489 Free PMC article.

10

Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole.

Methawasin M, Hutchinson KR, Lee EJ, Smith JE 3rd, Saripalli C, Hidalgo CG, Ottenheijm CA, Granzier H. Methawasin M, et al. Circulation. 2014 May 13;129(19):1924-36. doi: 10.1161/CIRCULATIONAHA.113.005610. Epub 2014 Mar 5. Circulation. 2014. PMID: 24599837 Free PMC article.

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