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Adult hematopoietic stem cells lacking Hif-1α self-renew normally.
Vukovic M, Sepulveda C, Subramani C, Guitart AV, Mohr J, Allen L, Panagopoulou TI, Paris J, Lawson H, Villacreces A, Armesilla-Diaz A, Gezer D, Holyoake TL, Ratcliffe PJ, Kranc KR. Vukovic M, et al. Among authors: sepulveda c. Blood. 2016 Jun 9;127(23):2841-6. doi: 10.1182/blood-2015-10-677138. Epub 2016 Apr 8. Blood. 2016. PMID: 27060169 Free PMC article.
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance.
Guitart AV, Subramani C, Armesilla-Diaz A, Smith G, Sepulveda C, Gezer D, Vukovic M, Dunn K, Pollard P, Holyoake TL, Enver T, Ratcliffe PJ, Kranc KR. Guitart AV, et al. Among authors: sepulveda c. Blood. 2013 Sep 5;122(10):1741-5. doi: 10.1182/blood-2013-02-484923. Epub 2013 Jul 26. Blood. 2013. PMID: 23894152 Free article.
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance.
Vukovic M, Guitart AV, Sepulveda C, Villacreces A, O'Duibhir E, Panagopoulou TI, Ivens A, Menendez-Gonzalez J, Iglesias JM, Allen L, Glykofrydis F, Subramani C, Armesilla-Diaz A, Post AE, Schaak K, Gezer D, So CW, Holyoake TL, Wood A, O'Carroll D, Ratcliffe PJ, Kranc KR. Vukovic M, et al. Among authors: sepulveda c. J Exp Med. 2015 Dec 14;212(13):2223-34. doi: 10.1084/jem.20150452. Epub 2015 Dec 7. J Exp Med. 2015. PMID: 26642852 Free PMC article.
Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions.
Guitart AV, Panagopoulou TI, Villacreces A, Vukovic M, Sepulveda C, Allen L, Carter RN, van de Lagemaat LN, Morgan M, Giles P, Sas Z, Gonzalez MV, Lawson H, Paris J, Edwards-Hicks J, Schaak K, Subramani C, Gezer D, Armesilla-Diaz A, Wills J, Easterbrook A, Coman D, So CW, O'Carroll D, Vernimmen D, Rodrigues NP, Pollard PJ, Morton NM, Finch A, Kranc KR. Guitart AV, et al. Among authors: sepulveda c. J Exp Med. 2017 Mar 6;214(3):719-735. doi: 10.1084/jem.20161087. Epub 2017 Feb 15. J Exp Med. 2017. PMID: 28202494 Free PMC article.
JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells.
Lawson H, Sepulveda C, van de Lagemaat LN, Durko J, Barile M, Tavosanis A, Georges E, Shmakova A, Timms P, Carter RN, Allen L, Campos J, Vukovic M, Guitart AV, Giles P, O'Shea M, Vernimmen D, Morton NM, Rodrigues NP, Göttgens B, Schofield CJ, Lengeling A, O'Carroll D, Kranc KR. Lawson H, et al. Among authors: sepulveda c. Blood Adv. 2021 Feb 9;5(3):889-899. doi: 10.1182/bloodadvances.2020002702. Blood Adv. 2021. PMID: 33560400 Free PMC article.
Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia.
Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H, Wotherspoon DA, Sepulveda C, Vukovic M, Allen L, Sarapuu A, Tavosanis A, Guitart AV, Villacreces A, Much C, Choe J, Azar A, van de Lagemaat LN, Vernimmen D, Nehme A, Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR. Paris J, et al. Among authors: sepulveda c. Cell Stem Cell. 2019 Jul 3;25(1):137-148.e6. doi: 10.1016/j.stem.2019.03.021. Epub 2019 Apr 25. Cell Stem Cell. 2019. PMID: 31031138 Free PMC article.
CITED2 coordinates key hematopoietic regulatory pathways to maintain the HSC pool in both steady-state hematopoiesis and transplantation.
Lawson H, van de Lagemaat LN, Barile M, Tavosanis A, Durko J, Villacreces A, Bellani A, Mapperley C, Georges E, Martins-Costa C, Sepulveda C, Allen L, Campos J, Campbell KJ, O'Carroll D, Göttgens B, Cory S, Rodrigues NP, Guitart AV, Kranc KR. Lawson H, et al. Among authors: sepulveda c. Stem Cell Reports. 2021 Nov 9;16(11):2784-2797. doi: 10.1016/j.stemcr.2021.10.001. Epub 2021 Oct 28. Stem Cell Reports. 2021. PMID: 34715054 Free PMC article.
245 results