Quan ML - Search Results

1

Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.

Corte JR, Fang T, Pinto DJ, Orwat MJ, Rendina AR, Luettgen JM, Rossi KA, Wei A, Ramamurthy V, Myers JE Jr, Sheriff S, Narayanan R, Harper TW, Zheng JJ, Li YX, Seiffert DA, Wexler RR, Quan ML. Corte JR, et al. Among authors: quan ml. Bioorg Med Chem. 2016 May 15;24(10):2257-72. doi: 10.1016/j.bmc.2016.03.062. Epub 2016 Apr 1. Bioorg Med Chem. 2016. PMID: 27073051

2

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.

Quan ML, Chiu AT, Ellis CD, Wong PC, Wexler RR, Timmermans PB. Quan ML, et al. J Med Chem. 1995 Jul 21;38(15):2938-45. doi: 10.1021/jm00015a016. J Med Chem. 1995. PMID: 7636854

3

Pharmacology of XR510, a potent orally active nonpeptide angiotensin II AT1 receptor antagonist with high affinity for the AT2 receptor subtype.

Wong PC, Quan ML, Saye JM, Bernard R, Crain EJ Jr, McCall DE, Watson CA, Zaspel AM, Smith RD, Wexler RR, et al. Wong PC, et al. Among authors: quan ml. J Cardiovasc Pharmacol. 1995 Sep;26(3):354-62. doi: 10.1097/00005344-199509000-00003. J Cardiovasc Pharmacol. 1995. PMID: 8583775

4

Pyrazoles, 1,2,4-triazoles, and tetrazoles as surrogates for cis-amide bonds in boronate ester thrombin inhibitors.

Duncia JV, Santella JB 3rd, Higley CA, VanAtten MK, Weber PC, Alexander RS, Kettner CA, Pruitt JR, Liauw AY, Quan ML, Knabb RM, Wexler RR. Duncia JV, et al. Among authors: quan ml. Bioorg Med Chem Lett. 1998 Apr 7;8(7):775-80. doi: 10.1016/s0960-894x(98)00104-8. Bioorg Med Chem Lett. 1998. PMID: 9871540

5

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 1.

Quan ML, Liauw AY, Ellis CD, Pruitt JR, Carini DJ, Bostrom LL, Huang PP, Harrison K, Knabb RM, Thoolen MJ, Wong PC, Wexler RR. Quan ML, et al. J Med Chem. 1999 Jul 29;42(15):2752-9. doi: 10.1021/jm980405i. J Med Chem. 1999. PMID: 10425086

6

Design and synthesis of isoxazoline derivatives as factor Xa inhibitors. 2.

Quan ML, Ellis CD, Liauw AY, Alexander RS, Knabb RM, Lam G, Wright MR, Wong PC, Wexler RR. Quan ML, et al. J Med Chem. 1999 Jul 29;42(15):2760-73. doi: 10.1021/jm980406a. J Med Chem. 1999. PMID: 10425087

7

Nonpeptide factor Xa inhibitors: I. Studies with SF303 and SK549, a new class of potent antithrombotics.

Wong PC, Quan ML, Crain EJ, Watson CA, Wexler RR, Knabb RM. Wong PC, et al. Among authors: quan ml. J Pharmacol Exp Ther. 2000 Jan;292(1):351-7. J Pharmacol Exp Ther. 2000. PMID: 10604970

8

Nonpeptide factor Xa inhibitors II. Antithrombotic evaluation in a rabbit model of electrically induced carotid artery thrombosis.

Wong PC, Crain EJ, Knabb RM, Meade RP, Quan ML, Watson CA, Wexler RR, Wright MR, Slee AM. Wong PC, et al. Among authors: quan ml. J Pharmacol Exp Ther. 2000 Oct;295(1):212-8. J Pharmacol Exp Ther. 2000. PMID: 10991981

9

Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa.

Pinto DJ, Orwat MJ, Wang S, Fevig JM, Quan ML, Amparo E, Cacciola J, Rossi KA, Alexander RS, Smallwood AM, Luettgen JM, Liang L, Aungst BJ, Wright MR, Knabb RM, Wong PC, Wexler RR, Lam PY. Pinto DJ, et al. Among authors: quan ml. J Med Chem. 2001 Feb 15;44(4):566-78. doi: 10.1021/jm000409z. J Med Chem. 2001. PMID: 11170646

10

Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.

Fevig JM, Pinto DJ, Han Q, Quan ML, Pruitt JR, Jacobson IC, Galemmo RA Jr, Wang S, Orwat MJ, Bostrom LL, Knabb RM, Wong PC, Lam PYS, Wexler RR. Fevig JM, et al. Among authors: quan ml. Bioorg Med Chem Lett. 2001 Mar 12;11(5):641-5. doi: 10.1016/s0960-894x(01)00029-4. Bioorg Med Chem Lett. 2001. PMID: 11266160

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