Fielder PJ - Search Results

1

Mechanism-Based Competitive Binding Model to Investigate the Effect of Neonatal Fc Receptor Binding Affinity on the Pharmacokinetic of Humanized Anti-VEGF Monoclonal IgG1 Antibody in Cynomolgus Monkey.

Ng CM, Fielder PJ, Jin J, Deng R. Ng CM, et al. Among authors: fielder pj. AAPS J. 2016 Jul;18(4):948-59. doi: 10.1208/s12248-016-9911-4. Epub 2016 Apr 13. AAPS J. 2016. PMID: 27075465

2

Use of quantitative pharmacology in the development of HAE1, a high-affinity anti-IgE monoclonal antibody.

Putnam WS, Li J, Haggstrom J, Ng C, Kadkhodayan-Fischer S, Cheu M, Deniz Y, Lowman H, Fielder P, Visich J, Joshi A, Jumbe NS. Putnam WS, et al. AAPS J. 2008 Jun;10(2):425-30. doi: 10.1208/s12248-008-9045-4. Epub 2008 Aug 7. AAPS J. 2008. PMID: 18686041 Free PMC article. Review.

3

Pharmacokinetics of humanized monoclonal anti-tumor necrosis factor-{alpha} antibody and its neonatal Fc receptor variants in mice and cynomolgus monkeys.

Deng R, Loyet KM, Lien S, Iyer S, DeForge LE, Theil FP, Lowman HB, Fielder PJ, Prabhu S. Deng R, et al. Among authors: fielder pj. Drug Metab Dispos. 2010 Apr;38(4):600-5. doi: 10.1124/dmd.109.031310. Epub 2010 Jan 13. Drug Metab Dispos. 2010. PMID: 20071453 Clinical Trial.

4

Modeling approach to investigate the effect of neonatal Fc receptor binding affinity and anti-therapeutic antibody on the pharmacokinetic of humanized monoclonal anti-tumor necrosis factor-α IgG antibody in cynomolgus monkey.

Ng CM, Loyet KM, Iyer S, Fielder PJ, Deng R. Ng CM, et al. Among authors: fielder pj. Eur J Pharm Sci. 2014 Jan 23;51:51-8. doi: 10.1016/j.ejps.2013.08.033. Epub 2013 Aug 31. Eur J Pharm Sci. 2014. PMID: 23999033

5

Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase I study.

Zheng Y, Scheerens H, Davis JC Jr, Deng R, Fischer SK, Woods C, Fielder PJ, Stefanich EG. Zheng Y, et al. Among authors: fielder pj. Clin Pharmacol Ther. 2011 Feb;89(2):283-90. doi: 10.1038/clpt.2010.311. Epub 2010 Dec 29. Clin Pharmacol Ther. 2011. PMID: 21191378 Clinical Trial.

6

A strategy for risk mitigation of antibodies with fast clearance.

Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. Hötzel I, et al. Among authors: fielder p. MAbs. 2012 Nov-Dec;4(6):753-60. doi: 10.4161/mabs.22189. MAbs. 2012. PMID: 23778268 Free PMC article.

7

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: what have we learned?

Deng R, Iyer S, Theil FP, Mortensen DL, Fielder PJ, Prabhu S. Deng R, et al. Among authors: fielder pj. MAbs. 2011 Jan-Feb;3(1):61-6. doi: 10.4161/mabs.3.1.13799. Epub 2011 Jan 1. MAbs. 2011. PMID: 20962582 Free PMC article.

8

Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.

Deng R, Meng YG, Hoyte K, Lutman J, Lu Y, Iyer S, DeForge LE, Theil FP, Fielder PJ, Prabhu S. Deng R, et al. Among authors: fielder pj. MAbs. 2012 Jan-Feb;4(1):101-9. doi: 10.4161/mabs.4.1.18543. MAbs. 2012. PMID: 22327433 Free PMC article.

9

Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers.

Ng CM, Stefanich E, Anand BS, Fielder PJ, Vaickus L. Ng CM, et al. Among authors: fielder pj. Pharm Res. 2006 Jan;23(1):95-103. doi: 10.1007/s11095-005-8814-3. Epub 2006 Nov 30. Pharm Res. 2006. PMID: 16308668

10

Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development.

Wang J, Iyer S, Fielder PJ, Davis JD, Deng R. Wang J, et al. Among authors: fielder pj. Biopharm Drug Dispos. 2016 Mar;37(2):51-65. doi: 10.1002/bdd.1952. Epub 2015 May 15. Biopharm Drug Dispos. 2016. PMID: 25869767 Review.

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