Zimmermann G - Search Results

1

Identification of pyrazolopyridazinones as PDEδ inhibitors.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI. Papke B, et al. Among authors: zimmermann g. Nat Commun. 2016 Apr 20;7:11360. doi: 10.1038/ncomms11360. Nat Commun. 2016. PMID: 27094677 Free PMC article.

2

Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H. Zimmermann G, et al. Nature. 2013 May 30;497(7451):638-42. doi: 10.1038/nature12205. Epub 2013 May 22. Nature. 2013. PMID: 23698361

3

Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEδ prenyl binding site.

Zimmermann G, Schultz-Fademrecht C, Küchler P, Murarka S, Ismail S, Triola G, Nussbaumer P, Wittinghofer A, Waldmann H. Zimmermann G, et al. J Med Chem. 2014 Jun 26;57(12):5435-48. doi: 10.1021/jm500632s. Epub 2014 Jun 11. J Med Chem. 2014. PMID: 24884780

4

Dissociation of the K-Ras4B/PDEδ complex upon contact with lipid membranes: membrane delivery instead of extraction.

Weise K, Kapoor S, Werkmüller A, Möbitz S, Zimmermann G, Triola G, Waldmann H, Winter R. Weise K, et al. Among authors: zimmermann g. J Am Chem Soc. 2012 Jul 18;134(28):11503-10. doi: 10.1021/ja305518h. Epub 2012 Jul 10. J Am Chem Soc. 2012. PMID: 22721555

5

Small-molecule modulation of Ras signaling.

Spiegel J, Cromm PM, Zimmermann G, Grossmann TN, Waldmann H. Spiegel J, et al. Among authors: zimmermann g. Nat Chem Biol. 2014 Aug;10(8):613-22. doi: 10.1038/nchembio.1560. Epub 2014 Jun 15. Nat Chem Biol. 2014. PMID: 24929527 Review.

6

Identification of novel PDEδ interacting proteins.

Küchler P, Zimmermann G, Winzker M, Janning P, Waldmann H, Ziegler S. Küchler P, et al. Among authors: zimmermann g. Bioorg Med Chem. 2018 May 1;26(8):1426-1434. doi: 10.1016/j.bmc.2017.08.033. Epub 2017 Aug 31. Bioorg Med Chem. 2018. PMID: 28935183

7

A Specific and Covalent JNK-1 Ligand Selected from an Encoded Self-Assembling Chemical Library.

Zimmermann G, Rieder U, Bajic D, Vanetti S, Chaikuad A, Knapp S, Scheuermann J, Mattarella M, Neri D. Zimmermann G, et al. Chemistry. 2017 Jun 16;23(34):8152-8155. doi: 10.1002/chem.201701644. Epub 2017 May 30. Chemistry. 2017. PMID: 28485044 Free PMC article.

8

DNA-encoded chemical libraries: foundations and applications in lead discovery.

Zimmermann G, Neri D. Zimmermann G, et al. Drug Discov Today. 2016 Nov;21(11):1828-1834. doi: 10.1016/j.drudis.2016.07.013. Epub 2016 Jul 28. Drug Discov Today. 2016. PMID: 27477486 Free PMC article. Review.

9

Hit-Validation Methodologies for Ligands Isolated from DNA-Encoded Chemical Libraries.

Zimmermann G, Li Y, Rieder U, Mattarella M, Neri D, Scheuermann J. Zimmermann G, et al. Chembiochem. 2017 May 4;18(9):853-857. doi: 10.1002/cbic.201600637. Epub 2017 Jan 30. Chembiochem. 2017. PMID: 28067010 Free PMC article.

10

Quantitative PCR is a Valuable Tool to Monitor the Performance of DNA-Encoded Chemical Library Selections.

Li Y, Zimmermann G, Scheuermann J, Neri D. Li Y, et al. Among authors: zimmermann g. Chembiochem. 2017 May 4;18(9):848-852. doi: 10.1002/cbic.201600626. Epub 2017 Mar 16. Chembiochem. 2017. PMID: 28220596 Free PMC article.

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