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Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors.
Deng G, Zhao B, Ma Y, Xu Q, Wang H, Yang L, Zhang Q, Guo TB, Zhang W, Jiao Y, Cai X, Zhang J, Liu H, Guan X, Lu H, Xiang J, Elliott JD, Lin X, Ren F. Deng G, et al. Among authors: cai x. Bioorg Med Chem. 2013 Nov 1;21(21):6349-58. doi: 10.1016/j.bmc.2013.08.046. Epub 2013 Sep 3. Bioorg Med Chem. 2013. PMID: 24055079
Discovery of a Novel Macrocyclic Noncovalent CDK7 Inhibitor for Cancer Therapy.
Lu H, Zhang Y, Liu J, Jiang T, Yu X, Zhang H, Liang T, Peng J, Cai X, Lan X, Ren J, Ge M, Zhang J, Shang J, Yu J, Ren H, Liu Q, Gao J, Tang L, Ding X, Zhang M, Aliper A, Lu Q, Zhou F, Lan J, Ren F, Zhavoronkov A. Lu H, et al. Among authors: cai x. J Med Chem. 2024 Nov 28;67(22):20580-20594. doi: 10.1021/acs.jmedchem.4c02098. Epub 2024 Nov 9. J Med Chem. 2024. PMID: 39520367
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