Xu H - Search Results

1

Discovery of CNS Penetrant CXCR2 Antagonists for the Potential Treatment of CNS Demyelinating Disorders.

Xu H, Lu H, Xu Z, Luan L, Li C, Xu Y, Dong K, Zhang J, Li X, Li Y, Liu G, Gong S, Zhao YG, Liu A, Zhang Y, Zhang W, Cai X, Xiang JN, Elliott JD, Lin X. Xu H, et al. Among authors: xu y, xu z. ACS Med Chem Lett. 2016 Feb 8;7(4):397-402. doi: 10.1021/acsmedchemlett.5b00489. eCollection 2016 Apr 14. ACS Med Chem Lett. 2016. PMID: 27096048 Free PMC article.

2

Discovery of thiadiazole amides as potent, S1P₃-sparing agonists of sphingosine-1-phosphate 1 (S1P₁) receptor.

Xu H, Zhang H, Luan L, Xu Y, Li C, Wang Y, Han F, Yang T, Ren F, Xiang JN, Elliott JD, Zhao Y, Guo TB, Lu H, Zhang W, Hirst D, Lindon M, Lin X. Xu H, et al. Among authors: xu y. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2456-9. doi: 10.1016/j.bmcl.2012.02.016. Epub 2012 Feb 15. Bioorg Med Chem Lett. 2012. PMID: 22386243

3

Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists.

Meng Q, Zhao B, Xu Q, Xu X, Deng G, Li C, Luan L, Ren F, Wang H, Xu H, Xu Y, Zhang H, Xiang JN, Elliott JD, Guo TB, Zhao Y, Zhang W, Lu H, Lin X. Meng Q, et al. Among authors: xu q, xu x, xu h, xu y. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2794-7. doi: 10.1016/j.bmcl.2012.02.083. Epub 2012 Mar 3. Bioorg Med Chem Lett. 2012. PMID: 22429468

4

Discovery of novel 1,2,4-thiadiazole derivatives as potent, orally active agonists of sphingosine 1-phosphate receptor subtype 1 (S1P(1)).

Ren F, Deng G, Wang H, Luan L, Meng Q, Xu Q, Xu H, Xu X, Zhang H, Zhao B, Li C, Guo TB, Yang J, Zhang W, Zhao Y, Jia Q, Lu H, Xiang JN, Elliott JD, Lin X. Ren F, et al. Among authors: xu q, xu h, xu x. J Med Chem. 2012 May 10;55(9):4286-96. doi: 10.1021/jm2016107. Epub 2012 Apr 20. J Med Chem. 2012. PMID: 22500954

5

Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment.

Lin S, Wang C, Ji M, Wu D, Lv Y, Zhang K, Dong Y, Jin J, Chen J, Zhang J, Sheng L, Li Y, Chen X, Xu H. Lin S, et al. Among authors: xu h. J Med Chem. 2018 Jul 26;61(14):6087-6109. doi: 10.1021/acs.jmedchem.8b00416. Epub 2018 Jul 9. J Med Chem. 2018. PMID: 29927604

6

Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors.

Sun Y, Fu R, Lin S, Zhang J, Ji M, Zhang Y, Wu D, Zhang K, Tian H, Zhang M, Sheng L, Li Y, Jin J, Chen X, Xu H. Sun Y, et al. Among authors: xu h. Bioorg Med Chem. 2021 Jan 1;29:115890. doi: 10.1016/j.bmc.2020.115890. Epub 2020 Nov 25. Bioorg Med Chem. 2021. PMID: 33285407

7

Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.

Kong Q, Pan W, Xu H, Xue Y, Guo B, Meng X, Luo C, Wang T, Zhang S, Yang Y. Kong Q, et al. Among authors: xu h. J Med Chem. 2021 Jun 24;64(12):8644-8665. doi: 10.1021/acs.jmedchem.1c00621. Epub 2021 Jun 3. J Med Chem. 2021. PMID: 34080858

8

Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy.

Dong Y, Fu R, Chen J, Zhang K, Ji M, Wang M, Jiang H, Ye W, Hu J, Li Y, Jin J, Chen X, Xu H. Dong Y, et al. Among authors: xu h. J Med Chem. 2021 Nov 25;64(22):16626-16640. doi: 10.1021/acs.jmedchem.1c01219. Epub 2021 Oct 22. J Med Chem. 2021. PMID: 34676759

9

Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.

Zhang J, Jiang H, Lin S, Wu D, Tian H, Jiang L, Cui Y, Jin J, Chen X, Xu H. Zhang J, et al. Among authors: xu h. J Med Chem. 2022 Jun 9;65(11):8011-8028. doi: 10.1021/acs.jmedchem.2c00530. Epub 2022 May 24. J Med Chem. 2022. PMID: 35609190

10

Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.

Lin S, Du T, Zhang J, Wu D, Tian H, Zhang K, Jiang L, Lu D, Sheng L, Li Y, Ji M, Chen X, Xu H. Lin S, et al. Among authors: xu h. J Med Chem. 2022 Dec 22;65(24):16372-16391. doi: 10.1021/acs.jmedchem.2c01208. Epub 2022 Dec 13. J Med Chem. 2022. PMID: 36511661

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